Dolutegravir Sodium and Ex-Lax Regular Strength Pills

• Generic Name: dolutegravir
• Dosage Forms: n.a.
• Other Brand Names: Tivicay

Treatment of HIV-1 infection in adults, adolescents, and pediatric patients weighing ≥30 kg; usually used in conjunction with 2 HIV NRTIs (dual NRTIs).

For initial treatment in antiretroviral-naive adults and adolescents, experts state that dolutegravir in conjunction with tenofovir alafenamide and emtricitabine or dolutegravir in conjunction with tenofovir disoproxil fumarate (tenofovir DF) and emtricitabine (or lamivudine) are recommended INSTI-based regimens. Dolutegravir in conjunction with abacavir and lamivudine (or emtricitabine) also is a recommended INSTI-based regimen for initial treatment, but use only in those who are HLA-B*5701 negative.

For initial treatment in antiretroviral-naive pediatric patients, experts state that an INSTI-based regimen of dolutegravir in conjunction with 2 NRTIs is a preferred regimen in those ≥6 years of age weighing ≥30 kg.

In antiretroviral-experienced adults and adolescents, dolutegravir usually used in INSTI-based regimens that include dolutegravir and an optimized background antiretroviral regimen (OBR).

In certain virologically suppressed antiretroviral-experienced adults (i.e., those with plasma HIV-1 RNA levels <50 copies/mL on a stable antiretroviral regimen for ≥6 months who have no known history of treatment failure and are infected with HIV-1 with no known substitutions associated with resistance to dolutegravir or rilpivirine), a 2-drug regimen of dolutegravir and rilpivirine can be used to replace the current regimen. If the 2-drug regimen is used in such adults, single-entity dolutegravir and single-entity rilpivirine can be used concomitantly or the commercially available fixed combination of dolutegravir and rilpivirine (dolutegravir/rilpivirine; Juluca) can be used.

Fixed combination containing abacavir, dolutegravir, and lamivudine (abacavir/dolutegravir/lamivudine; Triumeq) is used alone or in conjunction with other antiretrovirals in adults, adolescents, and pediatric patients weighing ≥40 kg. Do not use abacavir/dolutegravir/lamivudine alone in patients with suspected or confirmed INSTI-resistance substitutions; dosage of dolutegravir in the fixed combination insufficient in such patients.

Postexposure prophylaxis of HIV infection following nonoccupational exposure (nPEP) in individuals exposed to blood, genital secretions, or other potentially infectious body fluids that might contain HIV when the exposure represents a substantial risk for HIV transmission. Used in conjunction with other antiretrovirals.

When nPEP indicated in adults and adolescents ≥13 years of age with normal renal function, CDC states preferred regimen is either raltegravir or dolutegravir used in conjunction with emtricitabine and tenofovir DF (given as emtricitabine/tenofovir DF; Truvada); recommended alternative in these patients is ritonavir-boosted darunavir used in conjunction with emtricitabine/tenofovir DF.

Consult infectious disease specialist, clinician with expertise in administration of antiretroviral agents, and/or the National Clinicians’ Postexposure Prophylaxis Hotline (PEPline at 888-448-4911) if nPEP indicated in certain exposed individuals (e.g., pregnant women, children, those with medical conditions such as renal impairment) or if considering a regimen not included in CDC guidelines, source virus is known or likely to be resistant to antiretrovirals, or healthcare provider is inexperienced in prescribing antiretrovirals. Do not delay initiation of nPEP while waiting for expert consultation.

• Generic Name: senna
• Dosage Forms: n.a.
• Other Brand Names: Black Draught, Dr Caldwell Laxative, Ex-Lax Chocolated, Ex-Lax Maximum Relief Formula, Ex-Lax Regular Strength Pills, Fletchers Castoria, Innerclean, Little Tummys Laxative Drops, Pedia-Lax, Perdiem Overnight, Senexon, Senna Lax, Senna Smooth, Senna-gen, Senokot, Senokot Extra, Senokot To Go, SenokotXTRA, SenoSol, SenoSol-X, Senna, Evac-u-gen, Ex-Lax

Senna is also known as Cassia senna, tinnevelly senna, Indian senna, Alexandrian senna, and Khartoum senna.

Senna has been used in alternative medicine as an aid to treat constipation.

Not all uses for senna have been approved by the FDA. Senna should not be used in place of medication prescribed for you by your doctor.

Senna is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

Senna may also be used for purposes not listed in this product guide.