Dolutegravir Sodium and Rilpivirine Hydrochloride and Prilosec

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using rilpivirine together with omeprazole is not recommended. By reducing the acidity level in the stomach, omeprazole can decrease the absorption and blood levels of rilpivirine and make the medication less effective against HIV. Talk to a healthcare provider if you have any questions or concerns. Your doctor or pharmacist may be able to recommend alternatives that do not interact (or interact to a lesser extent) if you require treatment for stomach acid or ulcer while you are being treated with rilpivirine. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: Coadministration with proton pump inhibitors may significantly decrease the oral bioavailability of rilpivirine. The proposed mechanism involves a pH-dependent reduction in dissolution and absorption of rilpivirine, which is poorly soluble over a wide pH range. When a single 150 mg dose of rilpivirine was administered with omeprazole 20 mg once daily to 16 study subjects, mean rilpivirine peak plasma concentration (Cmax), systemic exposure (AUC) and trough plasma concentration (Cmin) decreased by 40%, 40% and 33%, respectively, compared to rilpivirine administered alone. No clinically significant changes in omeprazole Cmax and AUC were observed.

MANAGEMENT: Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiretroviral drug levels, concomitant use of rilpivirine with proton pump inhibitors is considered contraindicated.

Dolutegravir Sodium and Rilpivirine Hydrochloride

Generic Name: dolutegravir / rilpivirine

Brand name: Juluca

Synonyms: Dolutegravir and rilpivirine, Dolutegravir and Rilpivirine

What is Dolutegravir Sodium and Rilpivirine Hydrochloride?

Prilosec

Generic Name: omeprazole

Brand name: FIRST Omeprazole, Omeprazole + SyrSpend SF Alka, Prilosec, Prilosec OTC, Prilosec, Prilosec OTC, Zegerid>

Synonyms: n.a.

What is Prilosec?