Donepezil and Lapatinib Ditosylate
Determining the interaction of Donepezil and Lapatinib Ditosylate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with inhibitors of CYP450 2D6 and/or 3A4 may increase the plasma concentrations of donepezil, which is primarily metabolized by these isoenzymes. In a 7-day crossover study in 18 healthy volunteers, the potent CYP450 3A4 inhibitor ketoconazole (200 mg once daily) increased the mean peak plasma concentration (Cmax) and systemic exposure (AUC) of donepezil (5 mg once daily) by approximately 36% each. The clinical relevance of these increases is unknown.
- "Product Information. Aricept (donepezil)." Pfizer US Pharmaceuticals, New York, NY.
- Rojas-Fernandez C, Fisher C "Drug interactions and donepezil." J Am Geriat Soc 40 (2000): 597-8
- Tiseo PJ, Perdomo CA, Friedhoff LT "Concurrent administration of donepezil HCl and ketoconazole: assessment of pharmacokinetic changes following single and multiple doses." Br J Clin Pharmacol 46 (1998): 30-4
Generic Name: donepezil
Brand name: Aricept, Aricept ODT
Synonyms: n.a.
Generic Name: lapatinib
Brand name: Tykerb
Synonyms: Lapatinib
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Donepezil-Lariam
- Donepezil-Larin 1.5/30
- Donepezil-Larin 1/20
- Donepezil-Larin 24 Fe
- Donepezil-Larin Fe 1.5/30
- Donepezil-Larin Fe 1/20
- Lapatinib Ditosylate-Donepezil 23 mg Tablets
- Lapatinib Ditosylate-Donepezil and memantine
- Lapatinib Ditosylate-Donepezil ER Tablets
- Lapatinib Ditosylate-Donepezil Hydrochloride
- Lapatinib Ditosylate-Donepezil Orally Disintegrating Tablet
- Lapatinib Ditosylate-Donepezil Orally Disintegrating Tablets