Donepezil and Phenytoin Extended-Release Capsules
Determining the interaction of Donepezil and Phenytoin Extended-Release Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Phenytoin may reduce the blood levels and effects of donepezil. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with drugs that are inducers of the CYP450 3A4 and/or 2D6 enzymatic pathways may decrease the plasma concentrations of donepezil. The mechanism is accelerated clearance of donepezil due to enhanced CYP450 activities.
MANAGEMENT: While clinical data are lacking, the possibility of a diminished therapeutic response to donepezil should be considered in patients receiving concomitant inducer agents.
- "Product Information. Aricept (donepezil)." Pfizer US Pharmaceuticals, New York, NY.
Generic Name: donepezil
Brand name: Aricept, Aricept ODT
Synonyms: n.a.
Generic Name: phenytoin
Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt
Synonyms: Phenytoin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Donepezil-Phenytoin Infatabs
- Donepezil-Phenytoin injection
- Donepezil-Phenytoin Intravenous
- Donepezil-Phenytoin Oral Suspension
- Donepezil-Phenytoin Sodium
- Donepezil-Phenytoin Sodium, Prompt injection
- Phenytoin Extended-Release Capsules-Donepezil 23 mg Tablets
- Phenytoin Extended-Release Capsules-Donepezil and memantine
- Phenytoin Extended-Release Capsules-Donepezil ER Tablets
- Phenytoin Extended-Release Capsules-Donepezil Hydrochloride
- Phenytoin Extended-Release Capsules-Donepezil Orally Disintegrating Tablet
- Phenytoin Extended-Release Capsules-Donepezil Orally Disintegrating Tablets