Donepezil and memantine and Itraconazole Oral Solution
Determining the interaction of Donepezil and memantine and Itraconazole Oral Solution and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with inhibitors of CYP450 2D6 and/or 3A4 may increase the plasma concentrations of donepezil, which is primarily metabolized by these isoenzymes. In a 7-day crossover study in 18 healthy volunteers, the potent CYP450 3A4 inhibitor ketoconazole (200 mg once daily) increased the mean peak plasma concentration (Cmax) and systemic exposure (AUC) of donepezil (5 mg once daily) by approximately 36% each. The clinical relevance of these increases is unknown.
- "Product Information. Aricept (donepezil)." Pfizer US Pharmaceuticals, New York, NY.
- Rojas-Fernandez C, Fisher C "Drug interactions and donepezil." J Am Geriat Soc 40 (2000): 597-8
- Tiseo PJ, Perdomo CA, Friedhoff LT "Concurrent administration of donepezil HCl and ketoconazole: assessment of pharmacokinetic changes following single and multiple doses." Br J Clin Pharmacol 46 (1998): 30-4
Generic Name: donepezil / memantine
Brand name: Namzaric, Namzaric Titration Pack
Synonyms: Memantine and Donepezil
Generic Name: itraconazole
Brand name: Onmel, Sporanox, Sporanox PulsePak, Tolsura
Synonyms: Itraconazole
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Donepezil and memantine-Itraconazole Tablets
- Donepezil and memantine-Ivabradine
- Donepezil and memantine-Ivabradine Hydrochloride
- Donepezil and memantine-Ivabradine Oral Solution
- Donepezil and memantine-Ivabradine Tablets
- Donepezil and memantine-Ivacaftor
- Itraconazole Oral Solution-Donepezil ER Tablets
- Itraconazole Oral Solution-Donepezil Hydrochloride
- Itraconazole Oral Solution-Donepezil Orally Disintegrating Tablet
- Itraconazole Oral Solution-Donepezil Orally Disintegrating Tablets
- Itraconazole Oral Solution-Donepezil Tablets
- Itraconazole Oral Solution-Dong quai