Donepezil and memantine and Mifepristone Tablets
Determining the interaction of Donepezil and memantine and Mifepristone Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with inhibitors of CYP450 2D6 and/or 3A4 may increase the plasma concentrations of donepezil, which is primarily metabolized by these isoenzymes. In a 7-day crossover study in 18 healthy volunteers, the potent CYP450 3A4 inhibitor ketoconazole (200 mg once daily) increased the mean peak plasma concentration (Cmax) and systemic exposure (AUC) of donepezil (5 mg once daily) by approximately 36% each. The clinical relevance of these increases is unknown.
- "Product Information. Aricept (donepezil)." Pfizer US Pharmaceuticals, New York, NY.
- Rojas-Fernandez C, Fisher C "Drug interactions and donepezil." J Am Geriat Soc 40 (2000): 597-8
- Tiseo PJ, Perdomo CA, Friedhoff LT "Concurrent administration of donepezil HCl and ketoconazole: assessment of pharmacokinetic changes following single and multiple doses." Br J Clin Pharmacol 46 (1998): 30-4
Generic Name: donepezil / memantine
Brand name: Namzaric, Namzaric Titration Pack
Synonyms: Memantine and Donepezil
Generic Name: mifepristone
Brand name: Korlym, Mifeprex
Synonyms: Mifepristone
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Donepezil and memantine-Mifepristone Tablets (For Ending Early Pregnancy)
- Donepezil and memantine-Mifepristone Tablets (For High Blood Sugar)
- Donepezil and memantine-Migalastat
- Donepezil and memantine-Migalastat Hydrochloride
- Donepezil and memantine-Migergot
- Donepezil and memantine-Migergot Suppository
- Mifepristone Tablets-Donepezil ER Tablets
- Mifepristone Tablets-Donepezil Hydrochloride
- Mifepristone Tablets-Donepezil Orally Disintegrating Tablet
- Mifepristone Tablets-Donepezil Orally Disintegrating Tablets
- Mifepristone Tablets-Donepezil Tablets
- Mifepristone Tablets-Dong quai