Donepezil and memantine and Ramelteon Tablets
Determining the interaction of Donepezil and memantine and Ramelteon Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Talk to your doctor before using ramelteon together with donepezil. Combining these medications may significantly increase the blood levels and effects of ramelteon. This can lead to increased side effects such as excessive drowsiness, abnormal thinking, behavioral changes, and depression. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. You should avoid the use of alcohol while being treated with ramelteon. Avoid driving or operating hazardous machinery until you know how the medication affects you, and do not exceed the dosage or frequency of use prescribed by your doctor. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: The concomitant use of donepezil and ramelteon may increase the systemic exposure to ramelteon. The mechanism has not been reported. After administration of donepezil 10 mg/day for 26 days and a single 8 mg dose of ramelteon, the overall exposure (AUC) to ramelteon increased by approximately 100% and the Cmax increased by 87%.
MANAGEMENT: Close monitoring of patients is recommended during coadministration.
- "Product Information. Rozerem (ramelteon)." Takeda Pharmaceuticals America, Lincolnshire, IL.
Generic Name: donepezil / memantine
Brand name: Namzaric, Namzaric Titration Pack
Synonyms: Memantine and Donepezil
Generic Name: ramelteon
Brand name: Rozerem
Synonyms: Ramelteon
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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