Donepezil ER Tablets and Griseofulvin Microsize Tablets
Determining the interaction of Donepezil ER Tablets and Griseofulvin Microsize Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Griseofulvin may reduce the blood levels and effects of donepezil. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with drugs that are inducers of the CYP450 3A4 and/or 2D6 enzymatic pathways may decrease the plasma concentrations of donepezil. The mechanism is accelerated clearance of donepezil due to enhanced CYP450 activities.
MANAGEMENT: While clinical data are lacking, the possibility of a diminished therapeutic response to donepezil should be considered in patients receiving concomitant inducer agents.
- "Product Information. Aricept (donepezil)." Pfizer US Pharmaceuticals, New York, NY.
Generic Name: donepezil
Brand name: Aricept, Aricept ODT
Synonyms: Donepezil
Generic Name: griseofulvin
Brand name: Grifulvin V, Fulvicin P/G, Fulvicin U/F, Gris-PEG, Grisactin Ultra, Grisactin 250, Grisactin 500, Griseofulicin, Griseofulvic
Synonyms: Griseofulvin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Donepezil ER Tablets-Griseofulvin Tablets
- Donepezil ER Tablets-Griseofulvin Ultramicrosize Tablets
- Donepezil ER Tablets-Guaiatussin AC
- Donepezil ER Tablets-Guaifen DAC
- Donepezil ER Tablets-Guaifenesin AC Liquid
- Donepezil ER Tablets-Guaifenesin and Codeine
- Griseofulvin Microsize Tablets-Donepezil Hydrochloride
- Griseofulvin Microsize Tablets-Donepezil Orally Disintegrating Tablet
- Griseofulvin Microsize Tablets-Donepezil Orally Disintegrating Tablets
- Griseofulvin Microsize Tablets-Donepezil Tablets
- Griseofulvin Microsize Tablets-Dong quai
- Griseofulvin Microsize Tablets-Donnatal