Donepezil Tablets and Tezacaftor and Ivacaftor
Determining the interaction of Donepezil Tablets and Tezacaftor and Ivacaftor and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with inhibitors of CYP450 2D6 and/or 3A4 may increase the plasma concentrations of donepezil, which is primarily metabolized by these isoenzymes. In a 7-day crossover study in 18 healthy volunteers, the potent CYP450 3A4 inhibitor ketoconazole (200 mg once daily) increased the mean peak plasma concentration (Cmax) and systemic exposure (AUC) of donepezil (5 mg once daily) by approximately 36% each. The clinical relevance of these increases is unknown.
- "Product Information. Aricept (donepezil)." Pfizer US Pharmaceuticals, New York, NY.
- Rojas-Fernandez C, Fisher C "Drug interactions and donepezil." J Am Geriat Soc 40 (2000): 597-8
- Tiseo PJ, Perdomo CA, Friedhoff LT "Concurrent administration of donepezil HCl and ketoconazole: assessment of pharmacokinetic changes following single and multiple doses." Br J Clin Pharmacol 46 (1998): 30-4
Generic Name: donepezil
Brand name: Aricept, Aricept ODT
Synonyms: Donepezil
Generic Name: ivacaftor / tezacaftor
Brand name: Symdeko, Symdeko 4-Week
Synonyms: Ivacaftor and tezacaftor
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Donepezil Tablets-Tezacaftor/ivacaftor and ivacaftor
- Donepezil Tablets-TGQ 30PSE/3BRM/15DM
- Donepezil Tablets-TGQ 7.5PEH/4BRM/15DM
- Donepezil Tablets-TGT First Aid Antibiotic
- Donepezil Tablets-TGT First Aid Cleansing
- Donepezil Tablets-TH Antibiotic + Pain Relief
- Tezacaftor and Ivacaftor-Dong quai
- Tezacaftor and Ivacaftor-Donnatal
- Tezacaftor and Ivacaftor-Donnatal (Hyoscyamine, Atropine, Scopolamine, and Phenobarbital Elixir)
- Tezacaftor and Ivacaftor-Donnatal (Hyoscyamine, Atropine, Scopolamine, and Phenobarbital Tablets)
- Tezacaftor and Ivacaftor-Donnatal Elixir
- Tezacaftor and Ivacaftor-Donnatal Tablets