Donnatal (Hyoscyamine, Atropine, Scopolamine, and Phenobarbital Elixir) and Levothyroxine Sodium
Determining the interaction of Donnatal (Hyoscyamine, Atropine, Scopolamine, and Phenobarbital Elixir) and Levothyroxine Sodium and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using PHENobarbital together with levothyroxine can decrease the effects of PHENobarbital. This can cause fatigue, weight gain, constipation, and low blood pressure. Talk with your doctor before using these medications together, and report any side effects promptly. You may need a dose adjustment or thyroid tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Barbiturates may decrease exogenous thyroid plasma concentrations resulting in elevated thyroid stimulating hormone (TSH) and exacerbation of hypothyroidism. The mechanism may be induction of hepatic CYP450 enzymes responsible for thyroxine (T4) and triiodothyronine (T3) metabolism. Clinical data are limited.
MANAGEMENT: Clinical monitoring of patient response, including laboratory serum TSH concentrations, is recommended. Adjustment of thyroid replacement dosage may be indicated when initiating or discontinuing barbiturate therapy.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Multum Information Services, Inc. Expert Review Panel"
Generic Name: atropine / hyoscyamine / phenobarbital / scopolamine
Brand name: Donnatal, D-Tal, Phenohytro, Chardonna-2, Hyosophen, Donnapine, Elixiral, Bellatal, Spasmolin, Haponal, Antispas, Barbidonna, Donnatal Extentabs, Antispasmodic, Bellalphen, Donnaphen, Spasquid, Alkabel-SR, Bellatal ER, Servira, PB-Hyos, Quadrapax, Phenobarbital with Belladonna Alkaloids
Synonyms: Donnatal, Donnatal Elixir
Generic Name: levothyroxine
Brand name: Levothroid, Levoxyl, Synthroid, Unithroid, Tirosint, Euthyrox, Tirosint-Sol
Synonyms: Levothyroxine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Donnatal (Hyoscyamine, Atropine, Scopolamine, and Phenobarbital Elixir)-Levothyroxine Tablets
- Donnatal (Hyoscyamine, Atropine, Scopolamine, and Phenobarbital Elixir)-Levoxyl
- Donnatal (Hyoscyamine, Atropine, Scopolamine, and Phenobarbital Elixir)-Levsin
- Donnatal (Hyoscyamine, Atropine, Scopolamine, and Phenobarbital Elixir)-Levsin (Hyoscyamine Injection)
- Donnatal (Hyoscyamine, Atropine, Scopolamine, and Phenobarbital Elixir)-Levsin (Hyoscyamine Tablets)
- Donnatal (Hyoscyamine, Atropine, Scopolamine, and Phenobarbital Elixir)-Levsin Tablets
- Levothyroxine Sodium-Donnatal (Hyoscyamine, Atropine, Scopolamine, and Phenobarbital Tablets)
- Levothyroxine Sodium-Donnatal Elixir
- Levothyroxine Sodium-Donnatal Tablets
- Levothyroxine Sodium-Donor Prep Kit
- Levothyroxine Sodium-Dopamine
- Levothyroxine Sodium-Dopamine and Dextrose