Donnatal (Hyoscyamine, Atropine, Scopolamine, and Phenobarbital Elixir) and Verapamil Long-Acting Capsules
Determining the interaction of Donnatal (Hyoscyamine, Atropine, Scopolamine, and Phenobarbital Elixir) and Verapamil Long-Acting Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before taking verapamil, tell your doctor if you also use PHENobarbital. You may need dose adjustments or special tests in order to safely take both medications together. You should monitor your blood pressure more closely for changes while taking verapamil whenever PHENobarbital is started or stopped. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.
Professional:MONITOR: Some barbiturates may significantly decrease serum verapamil concentrations and half-life, especially with oral dosage forms. The mechanism is induction of CYP450 3A4 first-pass metabolism of verapamil.
MANAGEMENT: Close observation for reduced verapamil effect is recommended if these drugs must be used together. Dose adjustments may be required. Patients should also be monitored for verapamil toxicity after the barbiturate is discontinued.
- Rutledge DR, Pieper JA, Mirvis DM "Effects of chronic phenobarbital on verapamil dispostion in humans." J Pharmacol Exp Ther 246 (1988): 7-13
Generic Name: atropine / hyoscyamine / phenobarbital / scopolamine
Brand name: Donnatal, D-Tal, Phenohytro, Chardonna-2, Hyosophen, Donnapine, Elixiral, Bellatal, Spasmolin, Haponal, Antispas, Barbidonna, Donnatal Extentabs, Antispasmodic, Bellalphen, Donnaphen, Spasquid, Alkabel-SR, Bellatal ER, Servira, PB-Hyos, Quadrapax, Phenobarbital with Belladonna Alkaloids
Synonyms: Donnatal, Donnatal Elixir
Generic Name: verapamil
Brand name: Calan, Isoptin SR, Verelan, Isoptin, Calan SR, Isoptin IV, Covera-HS, Verelan PM
Synonyms: Verapamil
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Donnatal (Hyoscyamine, Atropine, Scopolamine, and Phenobarbital Elixir)-Verapamil Long-Acting Tablets
- Donnatal (Hyoscyamine, Atropine, Scopolamine, and Phenobarbital Elixir)-Verapamil oral/injection
- Donnatal (Hyoscyamine, Atropine, Scopolamine, and Phenobarbital Elixir)-Verapamil Sustained-Release Capsules
- Donnatal (Hyoscyamine, Atropine, Scopolamine, and Phenobarbital Elixir)-Verdeso
- Donnatal (Hyoscyamine, Atropine, Scopolamine, and Phenobarbital Elixir)-Verdrocet
- Donnatal (Hyoscyamine, Atropine, Scopolamine, and Phenobarbital Elixir)-Verelan
- Verapamil Long-Acting Capsules-Donnatal (Hyoscyamine, Atropine, Scopolamine, and Phenobarbital Tablets)
- Verapamil Long-Acting Capsules-Donnatal Elixir
- Verapamil Long-Acting Capsules-Donnatal Tablets
- Verapamil Long-Acting Capsules-Donor Prep Kit
- Verapamil Long-Acting Capsules-Dopamine
- Verapamil Long-Acting Capsules-Dopamine and Dextrose