Donnatal Tablets and Pexidartinib
Determining the interaction of Donnatal Tablets and Pexidartinib and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.GENERALLY AVOID: Coadministration of pexidartinib with strong CYP450 3A4 inducers may decrease the plasma concentrations and therapeutic effects of pexidartinib. The proposed mechanism is induction of CYP450 3A4, the isoenzyme responsible for the metabolic clearance of pexidartinib. Concomitant administration of rifampin, a strong CYP450 3A4 inducer, decreased pexidartinib peak plasma concentration (Cmax) and systemic exposure (AUC) by 33% and 65%, respectively. The effect of coadministration with a moderate CYP450 3A4 inducer on pexidartinib pharmacokinetics is unknown. MANAGEMENT: The use of pexidartinib with strong CYP450 3A4 inducers is not recommended. References "Product Information. Turalio (pexidartinib)." Daiichi Sankyo, Inc., Parsippany, NJ.
Professional:GENERALLY AVOID: Coadministration of pexidartinib with strong CYP450 3A4 inducers may decrease the plasma concentrations and therapeutic effects of pexidartinib. The proposed mechanism is induction of CYP450 3A4, the isoenzyme responsible for the metabolic clearance of pexidartinib. Concomitant administration of rifampin, a strong CYP450 3A4 inducer, decreased pexidartinib peak plasma concentration (Cmax) and systemic exposure (AUC) by 33% and 65%, respectively. The effect of coadministration with a moderate CYP450 3A4 inducer on pexidartinib pharmacokinetics is unknown.
MANAGEMENT: The use of pexidartinib with strong CYP450 3A4 inducers is not recommended.
- "Product Information. Turalio (pexidartinib)." Daiichi Sankyo, Inc., Parsippany, NJ.
Generic Name: atropine / hyoscyamine / phenobarbital / scopolamine
Brand name: Donnatal, D-Tal, Phenohytro, Chardonna-2, Hyosophen, Donnapine, Elixiral, Bellatal, Spasmolin, Haponal, Antispas, Barbidonna, Donnatal Extentabs, Antispasmodic, Bellalphen, Donnaphen, Spasquid, Alkabel-SR, Bellatal ER, Servira, PB-Hyos, Quadrapax, Phenobarbital with Belladonna Alkaloids
Synonyms: Belladonna alkaloids and phenobarbital, Hyoscyamine, Atropine, Scopolamine, and Phenobarbital
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Donnatal Tablets-Pexidartinib Hydrochloride
- Donnatal Tablets-Pfizerpen
- Donnatal Tablets-Pharaon Tea
- Donnatal Tablets-Pharmorubicin Pfs
- Donnatal Tablets-Phazyme
- Donnatal Tablets-Phazyme Liquid Gas Relief, Maximum Strength
- Pexidartinib-Donor Prep Kit
- Pexidartinib-Dopamine
- Pexidartinib-Dopamine and Dextrose
- Pexidartinib-Dopamine Hydrochloride
- Pexidartinib-Dopamine injection
- Pexidartinib-Dopamine Injection, Concentrate