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Dopamine injection and Stalevo 150

Determining the interaction of Dopamine injection and Stalevo 150 and the possibility of their joint administration.

Check result:

Dopamine injection <> Stalevo 150

Relevance: 13.09.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using DOPamine together with entacapone may increase your heart rate and blood pressure, and affect the rhythm of your heart . Contact your doctor if you experience increased side effects or if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: COMT inhibitors affect the elimination of drugs metabolized by catechol-O-methyltransferase (COMT) and may potentiate their effects. Arrhythmias, increased heart rate, and blood pressure changes may occur. Entacapone has increased heart rates up to 80% when coadministered with isoproterenol and epinephrine. Ventricular tachycardia has also been reported.

MANAGEMENT: The manufacturer recommends that caution be exercised when these drugs are given together. Monitoring for changes in hemodynamic status and ECG is recommended.

References

"Product Information. Tasmar (tolcapone)." Valeant Pharmaceuticals, Costa Mesa, CA.
"Product Information. Comtan (entacapone)" Novartis Pharmaceuticals, East Hanover, NJ.
Illi A, Sundberg S, Ojala-Karlsson P, Korhonen P, Scheinin M, Gordin A "The effect of entacapone on the disposition and hemodynamic effects of intravenous isoproterenol and epinephrine." Clin Pharmacol Ther 58 (1995): 221-7

Dopamine injection

Generic Name: dopamine

Brand name: Intropin

Synonyms: Dopamine Injection, DOPamine

What is Dopamine injection?

Stalevo 150

Generic Name: carbidopa / entacapone / levodopa

Brand name: Stalevo 100, Stalevo 125, Stalevo 150, Stalevo 200, Stalevo 50, Stalevo 75, Stalevo

Synonyms: n.a.

What is Stalevo 150?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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