Doravirine, Lamivudine, and Tenofovir Disoproxil Fumarate and Verapamil Sustained-Release Capsules
Determining the interaction of Doravirine, Lamivudine, and Tenofovir Disoproxil Fumarate and Verapamil Sustained-Release Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of doravirine, which is primarily metabolized by the isoenzyme. In 10 study subjects, administration of a single 50 mg dose of doravirine with the potent CYP450 3A4 inhibitor ritonavir (100 mg twice daily) increased doravirine peak plasma concentration (Cmax), systemic exposure (AUC) and trough plasma concentration (C24hr) by an average of 31%, 254% and 191%, respectively, compared to administration of doravirine alone. When a single 100 mg dose of doravirine was administered with ketoconazole 400 mg once daily in 10 study subjects, doravirine Cmax, AUC and C24hr increased by an average of 25%, 206% and 175%, respectively. These changes are not considered clinically significant.
- "Product Information. Pifeltro (doravirine)." Merck & Company Inc, Whitehouse Station, NJ.
Generic Name: doravirine / lamivudine / tenofovir
Brand name: Delstrigo
Synonyms: Doravirine, lamivudine, and tenofovir
Generic Name: verapamil
Brand name: Calan, Isoptin SR, Verelan, Isoptin, Calan SR, Isoptin IV, Covera-HS, Verelan PM
Synonyms: Verapamil
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Doravirine, Lamivudine, and Tenofovir Disoproxil Fumarate-Verdeso
- Doravirine, Lamivudine, and Tenofovir Disoproxil Fumarate-Verdrocet
- Doravirine, Lamivudine, and Tenofovir Disoproxil Fumarate-Verelan
- Doravirine, Lamivudine, and Tenofovir Disoproxil Fumarate-Verelan PM
- Doravirine, Lamivudine, and Tenofovir Disoproxil Fumarate-Veripred 20
- Doravirine, Lamivudine, and Tenofovir Disoproxil Fumarate-Vermox
- Verapamil Sustained-Release Capsules-Doribax
- Verapamil Sustained-Release Capsules-Doripenem
- Verapamil Sustained-Release Capsules-Doripenem Intravenous
- Verapamil Sustained-Release Capsules-Dornase Alfa
- Verapamil Sustained-Release Capsules-Dornase alfa inhalation
- Verapamil Sustained-Release Capsules-Dornase alfa Inhalation, oral/nebulization