Dorzolamide and Timolol Ophthalmic Solution and FusePaq Synapryn

• Generic Name: dorzolamide / timolol ophthalmic
• Dosage Forms: ophthalmic solution
• Other Brand Names: Cosopt, Cosopt PF

Dorzolamide ophthalmic reduces the amount of fluid in the eye, which decreases pressure inside the eye.

Timolol ophthalmic is a beta-blocker that also reduces pressure inside the eye.

Dorzolamide and timolol ophthalmic (for the eyes) is a combination medicine used to treat certain types of glaucoma and other causes of high pressure inside the eye.

Dorzolamide and timolol ophthalmic may also be used for purposes not listed in this medication guide.

• Generic Name: tramadol
• Dosage Forms: n.a.
• Other Brand Names: ConZip, Ultram, Ultram ER, Rybix ODT, Ryzolt

Tramadol is used to relieve moderate to moderately severe pain, including pain after surgery. The extended-release capsules or tablets are used for chronic ongoing pain.

Tramadol belongs to the group of medicines called opioid analgesics. It acts in the central nervous system (CNS) to relieve pain.

When tramadol is used for a long time, it may become habit-forming, causing mental or physical dependence. However, people who have continuing pain should not let the fear of dependence keep them from using narcotics to relieve their pain. Mental dependence (addiction) is not likely to occur when narcotics are used for this purpose. Physical dependence may lead to withdrawal side effects if treatment is stopped suddenly. However, severe withdrawal side effects can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped completely.

This medicine is available only under a restricted distribution program called the Opioid Analgesic REMS (Risk Evaluation and Mitigation Strategy) program.