Dorzolamide Hydrochloride and Minirin

• Generic Name: dorzolamide ophthalmic
• Dosage Forms: n.a.
• Other Brand Names: Trusopt

Reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.

Fixed-combination preparation containing dorzolamide and timolol (Cosopt) used topically to reduce elevated IOP in patients with open-angle glaucoma or ocular hypertension who have not responded adequately (i.e., failed to achieve target IOP as determined after multiple measurements over time) to a topical β-adrenergic blocking agent. Fixed-combination preparation associated with slightly smaller decrease in IOP than combination therapy with dorzolamide (administered 3 times daily) and timolol (administered twice daily).

A first-line “add-on” agent when more than one drug is needed. Add-on therapy with dorzolamide to existing timolol therapy is as effective and better tolerated than add-on therapy with pilocarpine.

Safety and efficacy not established for the treatment of acute angle-closure glaucoma.

Used prophylactically before neodymium yttrium aluminum garnet (Nd:YAG) laser posterior capsulotomy.

Administration of 1 drop (20 µL) of dorzolamide 2% 1 hour prior to capsulotomy is more effective in preventing postoperative increases in IOP than placebo and as effective as oral acetazolamide 125 mg administered 1 hour prior to the procedure.

• Generic Name: desmopressin
• Dosage Forms: n.a.
• Other Brand Names: DDAVP, Nocdurna, DDAVP nasal, DDAVP Rhinal Tube, Noctiva, Stimate

Desmopressin nasal spray is used to treat central cranial diabetes insipidus. This is a condition that causes the body to lose too much fluid and become dehydrated. It is also used to control frequent urination and increased thirst caused by certain types of brain injury or brain surgery. The Stimate® nasal spray is used to treat bleeding in patients with hemophilia A or von Willebrand disease (Type I).

Noctiva™ nasal spray is used to treat nocturnal polyuria in adults who awaken two or more times to urinate at night. Nocturnal polyuria is a condition where your body makes too much urine at night. Your doctor will need to measure your urine and the times that you urinate for 24 hours to determine if you have nocturnal polyuria.

Desmopressin is similar to a hormone that is produced in the body. It acts on the kidneys to reduce the flow of urine. For bleeding, desmopressin increases the blood levels of factor VIII and von Willebrand factor. This results in less bleeding for patients who have low levels of these agents.

This medicine is available only with your doctor's prescription.