Doxapram and Histex I/E

• Generic Name: doxapram
• Dosage Forms: injection
• Other Brand Names: Dopram

Treatment of drug-induced postanesthetic respiratory depression or apnea not caused by skeletal muscle relaxants.

Other supportive therapy preferred due to questionable benefit and high potential for toxicity with doxapram. Limited role due to availability of safer and shorter-acting anesthetic agents.

Has been used in conjunction with supportive measures to stimulate respiration and hasten arousal in patients with respiratory and CNS depression secondary to drug overdose (e.g., barbiturates, opiate analgesics, general anesthetics).

However, use as an analeptic is strongly discouraged by most clinicians; analeptic therapy largely abandoned in favor of intensive supportive care (e.g., mechanical ventilation, oxygenation, cardiovascular support) and specific antidotes (e.g., pure opiate antagonists).

Short-term use in patients with acute respiratory insufficiency associated with COPD.

Role in such patients is limited; other supportive therapy (i.e., noninvasive ventilation using either negative- or positive-pressure device) is preferred.

Has been used for the treatment of neonatal apnea, principally in combination with theophylline or caffeine.

Limited support for this use; no apparent advantage over methylxanthines and risk of substantial adverse effects with doxapram therapy. The commercially available injection contains benzyl alcohol; use of this preparation in neonates is not recommended. (See Pediatric Use under Cautions.)

Should not be used in conjunction with mechanical ventilation.

• Generic Name: carbinoxamine
• Dosage Forms: n.a.
• Other Brand Names: Arbinoxa, Karbinal ER, Ryvent, Histex PD, Histex CT, Carbinoxamine PD, Pediox, Histex I/E, Pediatex, Palgic, Histex Pd 12, Carboxine, Cordron NR, Pediatex 12, Mintex PD, Histex PD

Carbinoxamine is used to treat symptoms of seasonal (short-term) or perennial (long-term) allergies, such as sneezing, runny nose, itching, watery eyes, hives, skin rash, itching, or wheezing. It is also used to treat symptoms of allergic rhinitis, allergic conjunctivitis caused by inhaled allergens and foods, or allergic skin reactions. This medicine is an antihistamine.

Carbinoxamine is used with epinephrine to treat severe allergic reactions (anaphylaxis). It is also used to treat allergic reactions to blood or plasma.

This medicine is available only with your doctor's prescription.