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Doxazosin and Verelan PM

Determining the interaction of Doxazosin and Verelan PM and the possibility of their joint administration.

Check result:
Doxazosin <> Verelan PM
Relevance: 02.04.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Verapamil may add to the blood pressure lowering effects of doxazosin. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. Let your doctor know if you develop these symptoms and they do not go away after a few days or they become troublesome. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: The hypotensive effects of some calcium channel blockers and alpha-adrenergic blockers may be additive. The proposed mechanism is additive vasodilatory effects and inhibition of CYP450 hepatic metabolism of some alpha blockers by certain calcium channel blockers.

MANAGEMENT: Hemodynamic responses should be monitored during coadministration, especially during the first few weeks of therapy. Patients should be advised to take the alpha-blocker at bedtime and to notify their physician if they experience dizziness or syncope while awake.

References
  • Pasanisi F, Elliot HL, Meredith PA, McSharry DR, Reid JL "Combined alpha adrenoceptor antagonism and calcium channel blockage in normal subjects." Clin Pharmacol Ther 36 (1984): 716-23
  • Kiss I, Farsang C "Nifedipine-prazosin interaction in patients with essential hypertension." Cardiovasc Drugs Ther 3 (1989): 413-5
  • McTavish D, Sorkin EM "Verapamil: an updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension." Drugs 38 (1989): 19-76
  • "Product Information. Xatral (alfuzosin)." Sanofi-Synthelabo Canada Inc, Markham, ON.
  • Pool JL "Combination antihypertensive therapy with terazosin and other antihypertensive agents: results of clinical trials." Am Heart J 122 (1991): 926-31
  • Meredith PA, Elliot HL, Pasanisi F, Reid JL "Prazosin and verapamil: a pharmacokinetic and pharmacodynamic interaction?" Br J Clin Pharmacol 21 (1986): p85
Doxazosin

Generic Name: doxazosin

Brand name: Cardura, Cardura XL, Doxadura, Cascor, Carduran

Synonyms: n.a.

Verelan PM

Generic Name: verapamil

Brand name: Verelan PM, Calan, Calan SR, Isoptin SR, Verelan, Isoptin, Isoptin IV, Covera-HS

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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