Doxepin Capsules and Stiripentol
Determining the interaction of Doxepin Capsules and Stiripentol and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Stiripentol may increase the blood levels and effects of doxepin. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: The concomitant administration of stiripentol may significantly increase plasma concentrations, pharmacologic effects, and toxicities of drugs that are substrates of CYP450 2C19, 3A4, and/or 2D6. The mechanism is inhibition of cytochrome P-450 metabolism by stiripentol.
MANAGEMENT: Clinical and laboratory monitoring for altered efficacy and safety is recommended during concomitant use. Dosage adjustments may be required if increased plasma levels or effects are observed.
- EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid."
Generic Name: doxepin
Brand name: Sinequan, Sinequan, Silenor
Synonyms: Doxepin (Sinequan), Doxepin (Systemic)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Doxepin Capsules-Stiripentol Capsules
- Doxepin Capsules-Stiripentol Powder Packets
- Doxepin Capsules-Stivarga
- Doxepin Capsules-Stomach Relief - Regular Formula
- Doxepin Capsules-Stool Softener/Laxative
- Doxepin Capsules-Strattera
- Stiripentol-Doxepin Cream
- Stiripentol-Doxepin Hydrochloride
- Stiripentol-Doxepin Hydrochloride topical
- Stiripentol-Doxepin Oral Concentrate
- Stiripentol-Doxepin Oral Solution Concentrate
- Stiripentol-Doxepin Sinequan