Doxepin Cream and Etidronate Disodium

• Generic Name: doxepin topical
• Dosage Forms: cream
• Other Brand Names: Prudoxin, Zonalon

Doxepin is a tricyclic antidepressant. When applied to the skin, doxepin topical can help relieve itching but it will not treat symptoms of depression.

Doxepin topical (for use on skin) is used to treat itchy skin in adults with eczema or other skin conditions that can lead to repeated scratching and thickened skin.

Doxepin topical may also be used for purposes not listed in this medication guide.

• Generic Name: etidronate
• Dosage Forms: n.a.
• Other Brand Names: Didronel, Didronel IV.

Used in the treatment of moderate to severe symptomatic Paget disease of bone (osteitis deformans).

Efficacy not established in asymptomatic patients. May consider prophylactic treatment in patients with extensive involvement of the skull or spinal column and the possibility of irreversible neurologic damage or in those with extensive involvement threatening major joints or weight-bearing bones.

Less effective than risedronate or alendronate in the treatment of moderate to severe Paget disease of bone.

Relapse generally tends to occur within about 3–24 months in patients most likely to relapse (e.g., higher pretreatment markers of bone turnover).

Resistance is most likely to develop in patients receiving >1 course of therapy per year or those with higher pretreatment indices of bone turnover.

Used in the prevention and treatment of heterotopic ossification (myositis ossificans, ectopic calcification, periarticular ossification, or paraosteoarthropathy) following total hip arthroplasty or resulting from spinal cord injury.

Efficacy not established for treatment of idiopathic heterotopic ossification or heterotopic ossification associated with conditions other than total hip arthroplasty or spinal cord injury.

Bisphosphonates, including etidronate, have been used effectively for the prevention and treatment of glucocorticoid-induced osteoporosis.