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Doxepin Oral Concentrate and Ritalin SR

Determining the interaction of Doxepin Oral Concentrate and Ritalin SR and the possibility of their joint administration.

Check result:

Doxepin Oral Concentrate <> Ritalin SR

Relevance: 07.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Before taking doxepin, tell your doctor if you also use methylphenidate. You may need dose adjustments or special tests in order to safely take both medications together. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

Professional:

MONITOR: The coadministration with methylphenidate may increase the serum concentrations of tricyclic antidepressants (TCAs). Case reports involving primarily methylphenidate and imipramine have suggested favorable as well as unfavorable clinical effects from this combination. In vitro studies suggest that methylphenidate may inhibit the metabolism of imipramine and other TCAs, although the extent is probably subject to considerable interindividual variation.

MANAGEMENT: Pharmacologic response to TCAs should be monitored more closely whenever methylphenidate (racemic) or dexmethylphenidate (the more pharmacologically active d-enantiomer) is added to or withdrawn from therapy, and the TCA dosage adjusted as necessary.

References

Gwirtsman HE, Szuba MP, Toren L, Feist M "The antidepressant response to tricyclics in major depressives is accelerated with adjunctive use of methylphenidate." Psychopharmacol Bull 30 (1994): 157-64
Grob CS, Coyle JT "Suspected adverse methylphenidate-imipramine interactions in children." J Dev Behav Pediatr 7 (1986): 265-7
Meyers B "Treatment of imipramine-resistant depression and lithium-refractory mania through drug interactions." Am J Psychiatry 135 (1978): 1420-1
Cooper TB, Simpson GM "Concomitant imipramine and methylphenidate administration: a case report." Am J Psychiatry 130 (1973): 721
Zeidenberg P, Perel JM, Kanzler M, Wharton RN, Malitz S "Clinical and metabolic studies with imipramine in man." Am J Psychiatry 127 (1971): 1321-6
Burke MS, Josephson A, Lightsey A "Combined methylphenidate and imipramine complication." J Am Acad Child Adolesc Psychiatry 34 (1995): 403-4
Wharton RN, Perel JM, Dayton PG, Malitz S "A potential clinical use for methylphenidate with tricyclic antidepressants." Am J Psychiatry 127 (1971): 1619-25

Doxepin Oral Concentrate

Generic Name: doxepin

Brand name: Sinequan, Sinequan, Silenor

Synonyms: Doxepin (Sinequan), Doxepin (Systemic)

What is Doxepin Oral Concentrate?

Ritalin SR

Generic Name: methylphenidate

Brand name: Methylin ER, Ritalin SR, Adhansia XR, Aptensio XR, Concerta, Cotempla XR-ODT, Jornay PM, Metadate ER, Methylin, QuilliChew ER, Quillivant XR, Relexxii, Ritalin, Ritalin LA, Metadate CD, Daytrana

Synonyms: n.a.

What is Ritalin SR?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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