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Doxorubicin and Isoptin SR

Determining the interaction of Doxorubicin and Isoptin SR and the possibility of their joint administration.

Check result:

Doxorubicin <> Isoptin SR

Relevance: 26.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using DOXOrubicin together with verapamil may increase the effects of DOXOrubicin. Contact your doctor if you experience extreme fatigue, easy bruising or bleeding, black, bloody or tarry stools, fever, chills, irregular heartbeat, abdominal pain, yellowing of the skin or eyes, severe nausea, vomiting, diarrhea, and loss of appetite. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: In the presence of verapamil, doxorubicin accumulates within cells, the intracellular distribution of doxorubicin shifts from cytoplasm to nucleus, and the formation of doxorubicin-related DNA strand breaks is increased. In the presence of verapamil, doxorubicin peak plasma levels, terminal half-life, and volume of distribution are significantly increased, whereas plasma clearance is significantly decreased. Although verapamil can be used to enhance the cytotoxicity of doxorubicin and has been used to overcome tumor cell resistance to doxorubicin, it can also increase the risk of side effects.

MANAGEMENT: Close monitoring for doxorubicin toxicity (cardiac, hematologic, and hepatic) is recommended. A reduction in doxorubicin dosage may be necessary in some cases.

References

Tidefelt U, Juliusson G, Elmhorn-Rosenborg A, Peterson C, Paul C "Increased intracellular concentrations of doxorubicin in resistant lymphoma cells in vivo by concomitant therapy with verapamil and cyclosporin A." Eur J Haematol 52 (1994): 276-82
Garbrecht M, Mullerleile U "Verapamil in the prevention of adriamycin-induced cardiomyopathy." Klin Wochenschr 64 Suppl 7 (1986): 132-4
Bruno NA, Slate DL "Effect of exposure to calcium entry blockers on doxorubicin accumulation and cytotoxicity in multidrug-resistant cells." J Natl Cancer Inst 82 (1990): 419-24
Hu XF, Martin TJ, Bell DR, de Luise M, Zalcberg JR "Combined use of cyclosporin A and verapamil in modulating multidrug resistance in human leukemia cell lines." Cancer Res 50 (1990): 2953-7
Presant CA, Kennedy PS, Wiseman C, et al "Verapamil reversal of clinical doxorubicin resistance in human cancer. A Wilshire Oncology Medical Group pilot phase I-II study." Am J Clin Oncol 9 (1986): 355-7
Kerr DJ, Graham J, Cummings J, et al "The effect of verapamil on the pharmacokinetics of adriamycin." Cancer Chemother Pharmacol 18 (1986): 239-42
Gibby EM, Boyse O, Hill BT "Selective interactions of verapamil with anthraquinones in adriamycin- sensitive and -resistant murine and human tumour cell lines in vitro." Cancer Chemother Pharmacol 20 (1987): 5-7
Long JP Jr, Prout GR Jr, Wong YK, Lin CW "The effect of verapamil on a multi-drug resistant bladder carcinoma cell line and its potential as an intravesical chemotherapeutic agent." J Urol 143 (1990): 1053-6
Scheulen ME, Budach W, Skorzec M, Wiefelsputz JK, Seeber S "Influence of cyclosporin A on the pharmacokinetics and pharmacodynamics of doxorubicin (Meeting abstract)." Proc Annu Meet Am Assoc Cancer Res 34 (1993): a12711993
Ahmed NK, Munson HR, Martin LA, Fan D, Love SD, Newman RA "New modulators of multidrug resistance." Proc Annu Meet Am Assoc Cancer Res 33 (1992): a2844
Shoji Y, Fisher MH, Periasamy A, et al "Verapamil and cyclosporin A modulate doxorubicin toxicity by distinct mechanisms." Cancer Lett 57 (1991): 209-18

Doxorubicin

Generic Name: doxorubicin

Brand name: Adriamycin, Adriamycin RDF, Rubex, Adriamycin PFS

Synonyms: DOXOrubicin (Conventional)

What is Doxorubicin?

Isoptin SR

Generic Name: verapamil

Brand name: Calan SR, Isoptin SR, Calan, Verelan, Isoptin, Isoptin IV, Covera-HS, Verelan PM

Synonyms: n.a.

What is Isoptin SR?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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