Doxorubicin and Vincristine
Determining the interaction of Doxorubicin and Vincristine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Concurrent administration of vincristine and doxorubicin may lead to an earlier onset and/or an increased severity of side effects. The mechanism is the inhibition of the metabolism of both drugs by a hepatic cytochrome P-450 isoenzyme in the CYP 3A subfamily. The clinical significance of this interaction has not been established. If vincristine and doxorubicin are used concomitantly, caution and close observation are advised.
- Zhou-Pan XR, Seree E, Zhou XJ, et al "Involvement of human liver cytochrome P450 3A in vinblastine metabolism: drug interactions." Cancer Res 53 (1993): 5121-6
- "Product Information. Oncovin (vincristine)." Lilly, Eli and Company, Indianapolis, IN.
Generic Name: doxorubicin
Brand name: Adriamycin, Adriamycin RDF, Rubex, Adriamycin PFS
Synonyms: DOXOrubicin (Conventional)
Generic Name: vincristine
Brand name: Oncovin, Vincasar PFS
Synonyms: VinCRIStine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Doxorubicin-Vincristine (Liposomal)
- Doxorubicin-Vincristine Intravenous
- Doxorubicin-Vincristine liposome
- Doxorubicin-Vincristine liposome Intravenous
- Doxorubicin-Vincristine Sulfate
- Doxorubicin-Vinorelbine
- Vincristine-Doxorubicin (Conventional)
- Vincristine-Doxorubicin Hydrochloride
- Vincristine-Doxorubicin Intravenous
- Vincristine-Doxorubicin liposomal
- Vincristine-Doxorubicin liposome Intravenous
- Vincristine-Doxy 100