Doxorubicin (Conventional) and Toposar injection
Determining the interaction of Doxorubicin (Conventional) and Toposar injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Limited data have shown that etoposide (VP-16) can increase the plasma clearance and urinary excretion of doxorubicin. The half-life of doxorubicin is unaffected. The clinical significance of these data is unknown.
- Cummings J, Forrest GJ, Cunningham D, Gilchrist NL, Soukop M "Influence of polysorbate 80 (tween 80) and etoposide (VP-16-213 on the pharmacokinetics and urinary excretion of adriamycin and its metabolites in cancer patients." Cancer Chemother Pharmacol 17 (1987): 80-4
Generic Name: doxorubicin
Brand name: Adriamycin, Adriamycin RDF, Rubex, Adriamycin PFS
Synonyms: Doxorubicin, DOXOrubicin (Conventional)
Generic Name: etoposide
Brand name: Toposar, VePesid, Etopophos
Synonyms: Toposar (injection), Toposar
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Doxorubicin (Conventional)-Topotecan
- Doxorubicin (Conventional)-Topotecan Capsules
- Doxorubicin (Conventional)-Topotecan Hydrochloride
- Doxorubicin (Conventional)-Topotecan Injection
- Doxorubicin (Conventional)-Topotecan Injection, Concentrate
- Doxorubicin (Conventional)-Topotecan Intravenous
- Toposar injection-Doxorubicin Hydrochloride
- Toposar injection-Doxorubicin Intravenous
- Toposar injection-Doxorubicin liposomal
- Toposar injection-Doxorubicin liposome Intravenous
- Toposar injection-Doxy 100
- Toposar injection-Doxycycline