Doxorubicin Intravenous and Lidocaine Oropharyngeal Solution
Determining the interaction of Doxorubicin Intravenous and Lidocaine Oropharyngeal Solution and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Limited in vitro data have shown that the two local anesthetics, procaine and lidocaine, can act synergistically with doxorubicin to inhibit cell growth. Data suggest that clinically achievable concentrations of these drugs could enhance doxorubicin cytotoxicity. The clinical relevance of these data is unknown.
- Chlebowski RT, Block JB, Cundiff D, Dietrich MF "Doxorubicin cytotoxicity enhanced by local anesthetics in a human melanoma cell line." Cancer Treat Rep 66 (1982): 121-125
Generic Name: doxorubicin
Brand name: Adriamycin, Adriamycin RDF, Rubex, Adriamycin PFS
Synonyms: Doxorubicin, DOXOrubicin (Conventional)
Generic Name: lidocaine
Brand name: UAD Caine, Xylocaine HCl, Xylocaine-MPF, Lidoject 1, Xylocaine Dental Cartridges, Lidoject 2, Xylocaine Duo-Trach Kit, Xylocaine HCl For Spinal, L-Caine, Dilocaine, Nervocaine, Truxacaine, Anestacaine
Synonyms: Lidocaine injection, Lidocaine (Systemic)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Doxorubicin Intravenous-Lidocaine Patch
- Doxorubicin Intravenous-Lidocaine Rectal Cream
- Doxorubicin Intravenous-Lidocaine Rectal Cream and Gel
- Doxorubicin Intravenous-Lidocaine Skin Liquid
- Doxorubicin Intravenous-Lidocaine Spray
- Doxorubicin Intravenous-Lidocaine topical
- Lidocaine Oropharyngeal Solution-Doxorubicin liposomal
- Lidocaine Oropharyngeal Solution-Doxorubicin liposome Intravenous
- Lidocaine Oropharyngeal Solution-Doxy 100
- Lidocaine Oropharyngeal Solution-Doxycycline
- Lidocaine Oropharyngeal Solution-Doxycycline Calcium
- Lidocaine Oropharyngeal Solution-Doxycycline Capsules (Rosacea)