Doxorubicin liposomal and Retrovir (Zidovudine Injection)
Determining the interaction of Doxorubicin liposomal and Retrovir (Zidovudine Injection) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Ask your doctor before using zidovudine together with DOXOrubicin liposomal. Using these medications together may cause zidovudine to be less effective. This can also cause decreased bone marrow function and blood problems. Contact your doctor if you experience extreme fatigue, easy bruising or bleeding, black, bloody or tarry stools, or fever, chills, or other signs of infection. If your doctor does prescribe these medications together, you may need a dose adjustment or special tests to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Doxorubicin has been shown to inhibit the phosphorylation of zidovudine to its active triphosphate form in vitro. The mechanism and clinical significance of this interaction is unknown. However, the potential for diminished antiretroviral activity of zidovudine should be considered. In addition, the myelotoxic effects of these agents may be additive when given in combination.
MANAGEMENT: The concomitant use of zidovudine and doxorubicin should be avoided.
- "Product Information. Retrovir (zidovudine)." Glaxo Wellcome, Research Triangle Park, NC.
- Hoggard PG, Veal GJ, Wild MJ, Barry MG, Back DJ "Drug interactions with zidovudine phosphorylation in vitro." Antimicrob Agents Chemother 39 (1995): 1376-8
Generic Name: doxorubicin liposomal
Brand name: Doxil, Lipodox, Lipodox 50
Synonyms: DOXOrubicin (Liposomal)
Generic Name: zidovudine
Brand name: Retrovir
Synonyms: Retrovir (oral/injection), Retrovir
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Doxorubicin liposomal-Retrovir (Zidovudine Syrup)
- Doxorubicin liposomal-Retrovir Infusion
- Doxorubicin liposomal-Retrovir Intravenous
- Doxorubicin liposomal-Retrovir oral/injection
- Doxorubicin liposomal-Revatio
- Doxorubicin liposomal-Revatio Injection
- Retrovir (Zidovudine Injection)-Doxorubicin liposome Intravenous
- Retrovir (Zidovudine Injection)-Doxy 100
- Retrovir (Zidovudine Injection)-Doxycycline
- Retrovir (Zidovudine Injection)-Doxycycline Calcium
- Retrovir (Zidovudine Injection)-Doxycycline Capsules (Rosacea)
- Retrovir (Zidovudine Injection)-Doxycycline Capsules with Omega-3 and Vitamin E Capsules