Doxycycline Oral Suspension and Insulin degludec Subcutaneous
Determining the interaction of Doxycycline Oral Suspension and Insulin degludec Subcutaneous and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using doxycycline together with insulin or certain other diabetes medications may increase the risk of hypoglycemia, or low blood sugar. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. Talk to your doctor if you have any questions or concerns. You may need a dose adjustment or more frequent monitoring of your blood sugar to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Tetracyclines may enhance the hypoglycemic effect of insulin by increasing tissue sensitivity to exogenous insulin.
MANAGEMENT: Blood glucose should be monitored closely whenever tetracyclines are prescribed to patients on insulin, especially if they are elderly or have renal impairment. The insulin dosage may require adjustment if an interaction is suspected. Patients should be apprised of the signs and symptoms of hypoglycemia (e.g., headache, dizziness, drowsiness, nausea, hunger, tremor, weakness, sweating, palpitations), how to treat it, and to contact their physician if it occurs.
- Phillips PJ, Easterbrook G "Phenformin, tetracycline and lactic acidosis." Ann Intern Med 86 (1977): 111
- Dalpe-Scott M, Heick HM, Begin-Heick N "Insulin secretion in the obese (ob/ob) mouse: the effect of oxytetracycline on insulin release." Diabetes 32 (1983): 932-7
- Hiatt N, Bonorris G "Insulin response in pancreatectomized dogs treated with oxytetracycline." Diabetes 19 (1970): 307-11
- Dalpe-Scott M, Begin-Heick N "Oxytetracycline treatment improves the response to insulin in the spontaneously diabetic (BB) rat." Diabetes 31 (1982): 53-9
- Miller JB "Hypoglycaemic effect of oxytetracycline." BMJ 2 (1966): 1007
- Begin-Heick N, Heick HM, Norman MG "Regranulation of Islets of Langerhans and normalization of in vivo insulin secretion in ob/ob mice treated with oxytetracycline." Diabetes 28 (1979): 65-70
Generic Name: doxycycline
Brand name: Acticlate, Adoxa CK, Adoxa Pak, Adoxa TT, Alodox, Avidoxy, Doryx, Mondoxyne NL, Monodox, Morgidox, Oracea, Oraxyl, Periostat Targadox, Vibramycin Calcium, Vibramycin Hyclate, Vibramycin monohydrate, Vibra-Tabs, Adox Pak 2/100, Adoxa, Adoxa Pak 1/100, Adoxa Pak 1/150, Avidoxy, TargaDOX, Vibramycin, Doxy 100, TargaDOX
Synonyms: Doxycycline
Generic Name: insulin degludec
Brand name: Tresiba, Tresiba FlexTouch
Synonyms: Insulin degludec, Insulin Degludec
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Doxycycline Oral Suspension-Insulin detemir
- Doxycycline Oral Suspension-Insulin Detemir (Cartridges and Prefilled Syringes)
- Doxycycline Oral Suspension-Insulin Detemir (Vials)
- Doxycycline Oral Suspension-Insulin detemir Subcutaneous
- Doxycycline Oral Suspension-Insulin glargine
- Doxycycline Oral Suspension-Insulin Glargine (U-100) Cartridge Systems and Pens
- Insulin degludec Subcutaneous-Doxycycline Suspension
- Insulin degludec Subcutaneous-Doxycycline Syrup
- Insulin degludec Subcutaneous-Doxycycline Tablets
- Insulin degludec Subcutaneous-Doxycycline Tablets and Capsules
- Insulin degludec Subcutaneous-Doxycycline Tablets, Salicylic Acid Wash, and Sunscreen Lotion Kit
- Insulin degludec Subcutaneous-Doxycyline Suspension