Doxycycline Tablets, Salicylic Acid Wash, and Sunscreen Lotion Kit and Phenytoin Sodium
Determining the interaction of Doxycycline Tablets, Salicylic Acid Wash, and Sunscreen Lotion Kit and Phenytoin Sodium and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before using doxycycline, tell your doctor if you also use phenytoin. You may need a dose adjustment or special tests in order to safely take both medications together. This may decrease the effectiveness of doxycycline. If you take both medications together, tell your doctor if your infection worsens. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Phenytoin (and other hydantoins) may significantly decrease doxycycline half-life resulting in decreased antimicrobial effectiveness. The mechanism may be related to induction of doxycycline metabolism.
MANAGEMENT: Patients should be monitored for altered doxycycline efficacy. It may be necessary to increase doxycycline dosage. Alternative antimicrobial therapy with a different tetracycline or a different class of antimicrobial agent may be preferable.
- Neuvonen PJ, Penttila O, Lehtovaara R, Aho K "Effect of antiepileptic drugs on the elimination of various tetracycline derivatives." Eur J Clin Pharmacol 9 (1975): 147-54
- Penttila O, Neuvonen PJ, Aho K, Lehtovaara R "Interaction between doxycycline and some antiepileptic drugs." Br Med J 2 (1974): 470-2
Generic Name: doxycycline / salicylic acid topical
Brand name: Avidoxy DK
Synonyms: n.a.
Generic Name: phenytoin
Brand name: Dilantin, Dilantin Infatabs, Phenytek, Phenytoin Sodium, Prompt
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Doxycycline Tablets, Salicylic Acid Wash, and Sunscreen Lotion Kit-Phenytoin Sodium, Prompt injection
- Doxycycline Tablets, Salicylic Acid Wash, and Sunscreen Lotion Kit-Phenytoin Suspension
- Doxycycline Tablets, Salicylic Acid Wash, and Sunscreen Lotion Kit-Philith
- Doxycycline Tablets, Salicylic Acid Wash, and Sunscreen Lotion Kit-Phillips Milk of Magnesia
- Doxycycline Tablets, Salicylic Acid Wash, and Sunscreen Lotion Kit-Phisohex
- Doxycycline Tablets, Salicylic Acid Wash, and Sunscreen Lotion Kit-Phl-Fluoxetine
- Phenytoin Sodium-Doxycyline Suspension
- Phenytoin Sodium-Doxylamine
- Phenytoin Sodium-Doxylamine and phenylephrine
- Phenytoin Sodium-Doxylamine and Phenylephrine Tablets
- Phenytoin Sodium-Doxylamine and pseudoephedrine
- Phenytoin Sodium-Doxylamine and Pseudoephedrine Liquid