Doxylamine and pyridoxine and Phenytek
Determining the interaction of Doxylamine and pyridoxine and Phenytek and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using pyridoxine together with phenytoin may decrease the effects of phenytoin. Contact your doctor if your condition changes or if you experience loss of seizure control. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Large doses of pyridoxine (greater than 200 mg/day) may decrease the concentration of certain antiepileptic medications, including phenytoin and phenobarbital. The mechanism of this interaction is not known.
MANAGEMENT: If large doses of pyridoxine must be used concomitantly with these medications, close observation for evidence of altered anticonvulsant effect is recommended. Patients should be advised to notify their caregiver if they experience loss of seizure control.
- Hansson O, Sillanpaa M "Pyridoxine and serum concentration of phenytoin and phenobarbitone." Lancet 1 (1976): 256
Generic Name: doxylamine / pyridoxine
Brand name: Bonjesta, Diclegis
Synonyms: Doxylamine and Pyridoxine
Generic Name: phenytoin
Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Doxylamine and pyridoxine-Phenytoin
- Doxylamine and pyridoxine-Phenytoin Capsules
- Doxylamine and pyridoxine-Phenytoin Chewable Tablets
- Doxylamine and pyridoxine-Phenytoin Extended-Release Capsules
- Doxylamine and pyridoxine-Phenytoin Infatabs
- Doxylamine and pyridoxine-Phenytoin injection
- Phenytek-Doxylamine Succinate
- Phenytek-Dr Caldwell Laxative
- Phenytek-Dr. Caldwell Senna Laxative
- Phenytek-Dramamine
- Phenytek-Dramamine (Dimenhydrinate Chewable Tablets)
- Phenytek-Dramamine (Dimenhydrinate Tablets)