Doxylamine Succinate and Gallium Nitrate

• Generic Name: doxylamine
• Dosage Forms: n.a.
• Other Brand Names: Unisom, Nytol Maximum Strength, Aldex AN, Nitetime Sleep-Aid, Sleep Aid

Self-medication for short-term management of insomnia, particularly in individuals who have difficulty falling asleep.

Safety and efficacy not fully established; however, FDA states that, pending further accumulation of data, doxylamine-containing nighttime sleep aids approved for this use may continue to be marketed in the US.

Used in fixed combination with pyridoxine for treatment of nausea and vomiting of pregnancy in women not responding to conservative management.

Not studied in patients with hyperemesis gravidarum.

Temporary relief of rhinorrhea, sneezing, lacrimation, itching eyes, or oronasopharyngeal itching associated with allergic rhinitis (e.g., hay fever) or other upper respiratory allergies.

• Generic Name: gallium nitrate
• Dosage Forms: n.a.
• Other Brand Names: Ganite

Used in conjunction with adequate hydration for the management of symptomatic hypercalcemia associated with malignant neoplasms in patients whose hypercalcemia is not adequately managed with conventional methods of treatment (e.g., hydration alone); designated an orphan drug by FDA for this use.

More conservative measures than gallium therapy (e.g., hydration alone or combined with diuretics) generally are used for mild or asymptomatic hypercalcemia.

Has been used alone and in combination with other antineoplastic agents for the treatment of advanced or metastatic bladder carcinoma; however, other agents are preferred.