Dronedarone Hydrochloride and XaQuil XR

• Generic Name: dronedarone
• Dosage Forms: n.a.
• Other Brand Names: Multaq

Reduction of risk of hospitalization for atrial fibrillation in patients in sinus rhythm who have a history of paroxysmal or persistent atrial fibrillation.

Do not use in patients with permanent atrial fibrillation (i.e., patients in whom normal sinus rhythm will not or cannot be restored); increased risk of cardiovascular events and death in such patients. (See Warnings.)

Less effective than amiodarone in preventing recurrence of atrial fibrillation but appears to have an improved safety profile (based on short-term data). Long-term data and experience needed to elucidate relative safety and tolerability of dronedarone versus amiodarone because of some late-onset adverse effects of amiodarone (e.g., pulmonary toxicity).

Efficacy of retreatment with dronedarone in patients who relapse after initial successful treatment or in those who fail therapy with amiodarone not established.

Individualize treatment of atrial fibrillation/flutter based on relative benefits and risks of various therapies (e.g., rhythm versus rate control, nondrug therapies such as ablation and pacemaker implantation), patient age, and patient preference and tolerance of the arrhythmia.

• Generic Name: l-methylfolate
• Dosage Forms: n.a.
• Other Brand Names: Deplin, L-Methylfolate Formula, XaQuil XR, L-Methylfolate Formula 75

Folate is a form of B vitamin that occurs naturally in many foods. Folic acid is the man-made form of folate that is added to processed foods or vitamin and mineral supplements. Folate is needed in the human body for production of red blood cells.

A lack (deficiency) of folate in the human body can be caused by certain diseases, by taking certain medications, or by not getting enough folate in your diet. Folate deficiency can lead to decreased red blood cells, or anemia. Folate deficiency can also cause high levels of a certain amino acid in the blood, a condition called hyperhomocysteinemia (HYE-per-HOE-moe-sis-tin-EE-mee-a).

XaQuil XR is a medical food for use in people who have conditions related to folate deficiency. This medicine is also used in people with major depressive disorder who have folate deficiency, or in people with schizophrenia who have hyperhomocysteinemia related to folate deficiency.

XaQuil XR is not an antidepressant or anti-psychotic medication. However, this medicine may enhance the effects of antidepressant medications.

XaQuil XR may also be used for purposes not listed in this medication guide.