Droperidol Injection and Tranylcypromine Sulfate
Determining the interaction of Droperidol Injection and Tranylcypromine Sulfate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before getting anesthesia with droperidol, tell your doctor if you are taking tranylcypromine. Using these medications together may significantly affect your blood pressure. In some cases, your doctor may want you to stop taking tranylcypromine for 10 to 14 days before you undergo surgery. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:CONTRAINDICATED: Anecdotal reports have implicated the concomitant use of general anesthesia and nonselective monoamine oxidase inhibitors (MAOIs) as causing hypotension or hypertension. Analysis of these cases suggests that other contributing factors may have been involved (e.g., meperidine and sympathomimetic agents). The safe administration of general anesthetics to patients taking MAOIs has also been reported.
MANAGEMENT: The makers of MAOIs, both selective and nonselective, consider general anesthesia to be contraindicated in patients treated with MAOIs and recommend discontinuing MAOI therapy 10 to 14 days before elective surgery. However, this precaution is generally no longer considered necessary as long as patients are closely monitored during surgery and any adverse or idiosyncratic reactions are promptly managed.
- "Product Information. Azilect (rasagiline)." Teva Pharmaceuticals USA, North Wales, PA.
- "Product Information. Nardil (phenelzine)." Parke-Dvis, Morris Plains, NJ.
- "Product Information. Marplan (isocarboxazid)" Roche Laboratories, Nutley, NJ.
- "Product Information. Parnate (tranylcypromine)." SmithKline Beecham, Philadelphia, PA.
- "Product Information. Emsam (selegiline)." Bristol-Myers Squibb, Princeton, NJ.
Generic Name: droperidol
Brand name: Inapsine
Synonyms: Droperidol
Generic Name: tranylcypromine
Brand name: Parnate
Synonyms: Tranylcypromine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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