Drospirenone, ethinyl estradiol, and levomefolate and Trimethoprim
Determining the interaction of Drospirenone, ethinyl estradiol, and levomefolate and Trimethoprim and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using drospirenone together with trimethoprim may increase potassium levels in the blood. High levels of potassium can develop into a condition known as hyperkalemia, which in severe cases can lead to kidney failure, muscle paralysis, irregular heart rhythm, and cardiac arrest. You may be more likely to develop hyperkalemia while using these medications if you are elderly, dehydrated, or have kidney disease, diabetes, or advanced heart failure. Regular or long-term use of nonsteroidal anti-inflammatory drugs such as ibuprofen or naproxen (Aleve) may also increase your risk. It is important that you maintain adequate fluid intake during treatment with these medications, especially if you are using them for prolonged periods. In addition, talk to your doctor to see if you should limit consumption of potassium-rich foods such as tomatoes, raisins, figs, potatoes, lima beans, bananas, plantains, papayas, pears, cantaloupes, mangoes, and potassium-containing salt substitutes. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat, as these may be symptoms of hyperkalemia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: The use of drospirenone may potentiate the risk of hyperkalemia in patients receiving chronic treatment with drugs that can increase serum potassium such as angiotensin converting enzyme (ACE) inhibitors, angiotensin II receptor antagonists, potassium-sparing diuretics, aldosterone antagonists, nonsteroidal anti-inflammatory drugs (NSAIDs), potassium preparations, and miscellaneous agents like cyclosporine, heparin, tacrolimus, and trimethoprim. Drospirenone has antimineralocorticoid activity and may induce hyperkalemia in susceptible patients.
MANAGEMENT: Serum potassium levels should be checked regularly during concomitant therapy with drospirenone and other agents that can increase serum potassium. Particular caution is warranted in patients with renal impairment, diabetes, old age, severe or worsening heart failure, or dehydration. Patients should be advised to seek medical attention if they experience signs and symptoms of hyperkalemia such as nausea, vomiting, weakness, listlessness, tingling of the extremities, paralysis, confusion, weak pulse, and a slow or irregular heartbeat.
- Ponce SP, Jennings AE, Madias NE, Harrington JT "Drug-induced hyperkalemia." Medicine (Baltimore) 64 (1985): 357-70
- "Product Information. Yasmin (drospirenone-ethinyl estradiol)" Berlex Laboratories, Richmond, CA.
Generic Name: drospirenone / ethinyl estradiol / levomefolate calcium
Brand name: Beyaz, Safyral, Rajani, Tydemy
Synonyms: Ethinyl Estradiol, Drospirenone, and Levomefolate
Generic Name: trimethoprim
Brand name: Primsol, Trimpex, Proloprim
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Drospirenone, ethinyl estradiol, and levomefolate-Trimethoprim Oral Solution
- Drospirenone, ethinyl estradiol, and levomefolate-Trimethoprim Tablets
- Drospirenone, ethinyl estradiol, and levomefolate-Trimipramine
- Drospirenone, ethinyl estradiol, and levomefolate-Trimipramine Capsules
- Drospirenone, ethinyl estradiol, and levomefolate-Trimipramine Maleate
- Drospirenone, ethinyl estradiol, and levomefolate-Trimo San Jelly
- Trimethoprim-DroTuss-CP
- Trimethoprim-Droxia
- Trimethoprim-Droxidopa
- Trimethoprim-Dry Eye Omega Benefits
- Trimethoprim-DryMax
- Trimethoprim-DryMax Syrup