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Droxidopa and Poly-Vent DM (Guaifenesin, Pseudoephedrine, and Dextromethorphan Liquid)

Determining the interaction of Droxidopa and Poly-Vent DM (Guaifenesin, Pseudoephedrine, and Dextromethorphan Liquid) and the possibility of their joint administration.

Check result:

Droxidopa <> Poly-Vent DM (Guaifenesin, Pseudoephedrine, and Dextromethorphan Liquid)

Relevance: 01.10.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Treatment with droxidopa can cause a condition known as supine hypertension, which is high blood pressure while lying down. Combining droxidopa with other medications that can raise blood pressure can increase the risk. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. You should elevate the head of the bed when resting or sleeping to reduce the risk of supine hypertension. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Agents that increase blood pressure such as vasopressors, triptans, decongestants, beta-2 agonists, and amphetamines may potentiate the risk of supine hypertension associated with the use of droxidopa in the treatment of neurogenic orthostatic hypotension.

MANAGEMENT: Supine blood pressure should be monitored prior to and during droxidopa treatment, and more frequently when increasing dosage. Patients should elevate the head of the bed when resting or sleeping, and have blood pressure also measured in this position. Dosage reduction or discontinuation of droxidopa is recommended if supine hypertension cannot be managed by elevation of the head of the bed. Supine hypertension that is not well managed may increase the risk of cardiovascular events, particularly stroke.

References

"Product Information. Northera (droxidopa)." Chelsea Therapeutics Inc, Charlotte, NC.

Droxidopa

Generic Name: droxidopa

Brand name: Northera

Synonyms: n.a.

What is Droxidopa?

Poly-Vent DM (Guaifenesin, Pseudoephedrine, and Dextromethorphan Liquid)

Generic Name: dextromethorphan / guaifenesin / pseudoephedrine

Brand name: Poly-Vent DM, Tusnel-DM Pediatric Drops, Aldex GS DM, Capmist DM, Desgen, Despec-DM, Maxifed DM, Anatuss DM, Ambenyl-D, Dimacol, Novahistine DMX, Ru-Tuss Expectorant, Rhinosyn-X, Sudafed Cough, Dorcol Childrens Cough, Syn-Rx DM, Guaifenex DM RX, Suda-Tussin DM, Pseudogest-DM, Robitussin Pediatric Cough and Decongestant, Benylin Multi-Symptom Cough, Sudafed Cough Syrup, Daytime Liquicap, Multi Symptom Cough and Cold, Tussin Cough and Cold, Protuss DM, Med-RX DM, Tussafed-LA, Touro CC, Balminil DM-D-E Extra Strength, Benylin DM-D-E, Benylin DM-D-E Extra Strength, Calmylin #4, Novahistine DM Expectorant with Decongestant, Medent DM, Robitussin CF, Profen Forte DM, Profen II DM, Profen II DM Liquid, S-Pak DM, Ru-Tuss DM, Dimetapp Cold and Congestion, PanMist-DM, Relacon-DM, Coldmist DM, Z-COF DM, Ambifed-G DM, Tusnel Pediatric, Touro CC-LD, Relacon-DM NR, Despec Drops, Liquicough DM, Pseudo Cough, Relasin DM, Z-Cof 12DM, Q-Tussin CF, Ambi 60/580/30, Ambi 80/780/40, Ambi 600/1000/30, Trikof-D, Pseudo DM GG, Pseudo Max DMX, SudaTex-DM, ExeFen-DMX, Medent-DMI, Donatussin DM Syrup, Ambifed DM, Tenar DM, Robitussin D, ExeClear-DM, Z-Cof 8DM, Robitussin D Cough & Cold, TL-Dex DM, Tusnel DM Pediatric Drops, Trispec PSE

Synonyms: Poly-Vent DM (Liquid)

What is Poly-Vent DM (Guaifenesin, Pseudoephedrine, and Dextromethorphan Liquid)?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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