Duavee (combination) and Pramipexole Dihydrochloride

• Generic Name: bazedoxifene / conjugated estrogens
• Dosage Forms: n.a.
• Other Brand Names: Duavee

Bazedoxifene/conjugated estrogens in fixed combination: Prevention of osteoporosis in postmenopausal women with an intact uterus.

Not FDA-labeled for treatment of osteoporosis in postmenopausal women in the US. Bazedoxifene commercially available in other countries for this use.

Not recommended for prevention of osteoporosis in premenopausal women; safety and efficacy not established.

Bazedoxifene/conjugated estrogens in fixed combination: Management of moderate to severe vasomotor symptoms associated with menopause in women with an intact uterus.

• Generic Name: pramipexole
• Dosage Forms: n.a.
• Other Brand Names: Mirapex, Mirapex ER

Symptomatic management of idiopathic parkinsonian syndrome.

Used as an adjunct to levodopa for the symptomatic management of parkinsonian syndrome in patients with advanced disease.

Also used as monotherapy for the initial symptomatic management of parkinsonian syndrome. Most clinicians would use levodopa for initial therapy in individuals >70 years of age (less likely than younger individuals to develop levodopa-related motor complications and because of concerns about cognitive dysfunction), in patients with cognitive impairment, and in those with severe disease. A dopamine receptor agonist may be preferred for initial therapy in patients ≤70 years of age.

Symptomatic management of moderate-to-severe primary restless legs syndrome (Ekbom syndrome).