Dulcolax Stool Softener and Pitavastatin Calcium, Pitavastatin Magnesium

• Generic Name: docusate
• Dosage Forms: n.a.
• Other Brand Names: Dulcolax Stool Softener, Colace, Colace Microenema, Enemeez Mini, Diocto, Doc-Q-Lace, Docu, Doculase, Docusil, Docusoft S, DocuSol, Kao-Tin, Pedia-Lax Stool Softener, Phillips Stool Softener, Promolaxin, Silace, Surfak Stool Softener, Sur-Q-Lax, Dialose, DC-240, Kasof, DOK, Sulfalax Calcium, DOS, DSS, Modane Soft, Regulax SS, Dioeze, Aqualax, Dioctocal, Dioctosoftez, Dioctyn, Dionex, Docu Soft, Docucal, Calcium Stool Softener, Calube, D-S Caps, Ex-Lax Stool Softener, Genasoft, Doss-Relief, Fleet Sof-Lax, Colace Micro-Enema, Correctol Softgel Extra Gentle, Therevac-SB, Octycine-100, Octycine-250, Sulfolax, Kaopectate Stool Softener, Vacuant, Docuprene, DocuSol Kids, Colace Clear, Docusate Mini, Surfak

Dulcolax Stool Softener (docusate) makes bowel movements softer and easier to pass.

Dulcolax Stool Softener 100mg capsules are used to treat or prevent occasional constipation.

Dulcolax Stool Softener is also used to reduce pain or rectal damage caused by hard stools or by straining during bowel movements.

• Generic Name: pitavastatin
• Dosage Forms: n.a.
• Other Brand Names: Livalo, Zypitamag

Available as pitavastatin calcium (e.g., Livalo) and pitavastatin magnesium (i.e., Zypitamag). FDA considers pitavastatin magnesium tablets to be a pharmaceutical alternative (as described in section 505[b][2] of the Federal Food, Drug, and Cosmetic Act) and not a pharmaceutical (generic) equivalent to pitavastatin calcium tablets, since both contain the same active moiety (pitavastatin) but have different salts. Clinical efficacy and safety expected to be similar between the 2 salt forms of the drug.

Dyslipidemias

Adjunct to nondrug therapies (e.g., dietary management) to decrease elevated serum total cholesterol, LDL-cholesterol, apolipoprotein B (apo B), and triglyceride concentrations, and to increase HDL-cholesterol concentrations in the management of primary hypercholesterolemia or mixed dyslipidemia. Also used in combination with fenofibrate to decrease triglyceride concentrations and increase HDL-cholesterol concentrations in patients with mixed dyslipidemia and CHD (or CHD risk equivalents) who are on optimal statin therapy; however, no incremental benefit on cardiovascular morbidity and mortality beyond that provided by statin monotherapy.

Reductions in LDL-cholesterol concentrations achieved with usual dosages (1–4 mg daily) of pitavastatin are similar to or greater than those achieved with low to medium dosages of certain other statins (i.e., atorvastatin, pravastatin, simvastatin).

Safety and efficacy not established in patients with Fredrickson type I, III, or V dyslipidemia. Effect on cardiovascular morbidity and mortality not established.

Prevention of Cardiovascular Events

ACC/AHA cholesterol management guideline recommends statins as first-line therapy for prevention of atherosclerotic cardiovascular disease (ASCVD) in adults; extensive evidence demonstrates that statins can substantially reduce ASCVD risk when used for secondary prevention or primary prevention (in high-risk patients). Relative reduction in ASCVD risk is correlated with degree of LDL-cholesterol lowering; therefore, use maximum tolerated statin intensity to achieve optimum ASCVD benefits. According to ACC/AHA, pitavastatin may be used for primary or secondary prevention in adults when moderate-intensity statin therapy is indicated.