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Duo-Vil 2-10 and Seconal Sodium

Determining the interaction of Duo-Vil 2-10 and Seconal Sodium and the possibility of their joint administration.

Check result:

Duo-Vil 2-10 <> Seconal Sodium

Relevance: 09.07.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using amitriptyline together with secobarbital can cause either medication to be less effective. This could be especially dangerous if you are using secobarbital to prevent seizures. Talk to your doctor before using these medications together. You may need a dose adjustment or special tests to safely take these medications together. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Tricyclic antidepressants may counteract the anticonvulsive effects of barbiturates by lowering the seizure threshold. Barbiturates may decrease the serum levels and effects of tricyclic antidepressants by induction of hepatic metabolism. In addition, the respiratory-depressant effects of both agents may be increased due to additive pharmacologic effects.

MANAGEMENT: If the barbiturate is being taken for a seizure disorder, patients should be closely monitored for loss of seizure control. Dose adjustments may be required. Monitoring for clinical evidence of additive toxicity and for clinical and/or laboratory evidence of reduced antidepressant effect is also advisable.

References

Silverman G, Braithwaite R "Interaction of benzodiazepines with tricyclic antidepressants." Br Med J 4 (1972): 111
Spina E, Avenoso A, Campo GM, Caputi AP, Perucca E "Phenobarbital induces the 2-hydroxylation of desipramine." Ther Drug Monit 18 (1996): 60-4
Crocker J, Morton B "Tricyclic (antidepressant) drug toxicity." Clin Toxicol 2 (1969): 397-402
Garey KW, Amsden GW, Johns CA "Possible interaction between imipramine and butalbital." Pharmacotherapy 17 (1997): 1041-2
Burrows GD, Davies B "Antidepressants and barbiturates." Br Med J 4 (1971): 113

Duo-Vil 2-10

Generic Name: amitriptyline / perphenazine

Brand name: Etrafon Forte, Triavil, Etrafon 2-10, Etrafon 2-25

Synonyms: Duo-Vil 2-10 (Oral)

What is Duo-Vil 2-10?

Seconal Sodium

Generic Name: secobarbital

Brand name: Seconal Sodium, Seconal

Synonyms: n.a.

What is Seconal Sodium?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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