Dupilumab and Neoral

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Dupilumab may alter the blood levels of cycloSPORINE, which may make the medication less safe or effective in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Dupilumab, an interleukin-4 (IL-4) receptor antagonist, may alter the formation of CYP450 enzymes, which could lead to altered metabolism of CYP450 substrates. CYP450 enzyme formation can be altered by increased cytokines during chronic inflammation.

MANAGEMENT: Consider monitoring pharmacologic response and/or therapeutic concentration of CYP450 substrates, especially those with a narrow therapeutic index, more closely whenever dupilumab is added to or withdrawn from therapy, and consider adjusting the dose of the CYP450 substrate as necessary.

Dupilumab

Generic Name: dupilumab

Brand name: Dupixent

Synonyms: n.a.

What is Dupilumab?

Neoral

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Neoral (Capsules, Modified)

What is Neoral?