Duraclon and Phentolamine

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using cloNIDine together with phentolamine. Combining these medications may cause excessive slowing of your heart rate that can lead to serious or life-threatening cardiac complications. In addition, there is evidence to suggest that medications like phentolamine may reduce the effectiveness of cloNIDine in lowering blood pressure, although some data do not support this. Contact your doctor if you develop dizziness, lightheadedness, fainting, shortness of breath, chest pain, or heart palpitations during treatment with these medications. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration of clonidine with other sympatholytic drugs such as alpha-adrenergic blockers may produce additive effects on the sinus and atrioventricular (AV) nodes, potentially causing sinus node dysfunction and AV block. There have been postmarketing reports of patients with conduction abnormalities and/or concomitant use of other sympatholytic drugs who developed severe bradycardia while taking clonidine. Intravenous atropine, isoproterenol, and temporary cardiac pacing were required in some cases.

MONITOR: Limited data suggest that the antihypertensive effects of clonidine may be antagonized by prazosin and possibly other alpha-adrenergic blockers. The exact mechanism of interaction is unknown, and data are conflicting. In a study of 18 patients with essential hypertension, prazosin given for 4 days at an average dosage of 11 mg three times daily decreased the hypotensive effect of a single 150 mcg intravenous dose of clonidine by nearly 50%. Animal data have also supported this finding. In contrast, several clinical studies found neither a significant additive antihypertensive effect nor reduced effects of clonidine when combined with prazosin, and a study of ten patients with hypertension not controlled by a treatment including clonidine (300 to 450 microgram/day) reported that progressive addition of prazosin 4 to 22.5 mg/day led to control of hypertension in nine cases (mean supine blood pressure decreased from 174/102 to 144/88 mmHg). Additionally, a protective effect of prazosin against clonidine withdrawal syndrome (hypertensive rebound) was observed in 13 hospitalized patients whose clonidine was abruptly interrupted while prazosin was continued.

MANAGEMENT: Close clinical monitoring of hemodynamic response and tolerance is recommended if clonidine is prescribed with an alpha-adrenergic blocker, and the dosage of one or both agents adjusted as necessary.

Duraclon

Generic Name: clonidine

Brand name: Duraclon, Catapres, Catapres-TTS, Kapvay, Catapres-TTS-1, Catapres-TTS-2, Catapres-TTS-3

Synonyms: Duraclon (injection), Duraclon Injection

What is Duraclon?

Phentolamine

Generic Name: phentolamine

Brand name: OraVerse

Synonyms: n.a.

What is Phentolamine?