Duraclon injection and Fentanyl Lozenge
Determining the interaction of Duraclon injection and Fentanyl Lozenge and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:One study has suggested that clonidine may markedly reduce the fentanyl dosage required for prevention of hyperdynamic cardiovascular responses to laryngoscopy and intubation. The authors proposed that synergistic inhibitory actions of opiates and alpha-2-adrenoreceptor agonists on central sympathetic outflow may have accounted for reduced fentanyl requirement.
- Rostaing S, Bonnet F, Levron JC, et al "Effect of epidural clonidine on analgesia and pharmacokinetics of epidural fentanyl in postoperative patients." Anesthesiology 75 (1991): 420-5
- Ghignone M, Quintin L, Duke PC, Kehler CH, Calvillo O "Effects of clonidine on narcotic requirements and hemodynamic response during induction of fentanyl anesthesia and endotracheal intubation." Anesthesiology 64 (1986): 36-42
- Murga G, Samso E, Valles J, Casanovas P, Puig MM "The effect of clonidine on intra-operative requirements of fentanyl during combined epidural/general anaesthesia." Anaesthesia 49 (1994): 999-1002
Generic Name: clonidine
Brand name: Duraclon, Catapres, Catapres-TTS, Kapvay, Catapres-TTS-1, Catapres-TTS-2, Catapres-TTS-3
Synonyms: Duraclon (injection), Duraclon Injection
Generic Name: fentanyl
Brand name: Duragesic, Abstral, Fentora, Subsys, Actiq, Ionsys, Lazanda, Onsolis, Sublimaze
Synonyms: Fentanyl Patch, FentaNYL
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Duraclon injection-Fentanyl nasal
- Duraclon injection-Fentanyl Nasal Spray
- Duraclon injection-Fentanyl Novaplus Patch
- Duraclon injection-Fentanyl Sublingual Spray
- Duraclon injection-Fentanyl Sublingual Tablet
- Duraclon injection-Fentanyl Transdermal
- Fentanyl Lozenge-Duraflu
- Fentanyl Lozenge-Duraganidin NR
- Fentanyl Lozenge-Duragesic
- Fentanyl Lozenge-Duragesic Mat
- Fentanyl Lozenge-Duragesic-100 skin patch
- Fentanyl Lozenge-Durahist D