Duvelisib and Sudafed PE Pressure+Pain+Cold

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Duvelisib may increase the blood levels and effects of acetaminophen. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects during treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with duvelisib may increase the plasma concentrations of drugs that are primarily metabolized by the CYP450 3A4 isoenzyme. The mechanism is reduced clearance due to inhibition of CYP450 3A4 by duvelisib. The interaction may be particularly important for sensitive CYP450 3A4 substrates or those that demonstrate a narrow therapeutic index. When a single 2 mg oral dose of midazolam, a sensitive CYP450 3A4 substrate, was administered to 14 healthy adult study subjects following multiple doses of duvelisib 25 mg twice daily for 5 days, midazolam peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 2.2- and 4.3-fold, respectively.

MANAGEMENT: Caution is advised if duvelisib is used in combination with sensitive CYP450 3A4 substrates or those that demonstrate a narrow therapeutic index (e.g., ergot alkaloids, colchicine, fentanyl, macrolide immunosuppressants, midazolam, triazolam, vinca alkaloids). Dosage adjustments as well as clinical and laboratory monitoring may be appropriate whenever duvelisib is added to or withdrawn from therapy.

Duvelisib

Generic Name: duvelisib

Brand name: Copiktra

Synonyms: n.a.

What is Duvelisib?

Sudafed PE Pressure+Pain+Cold

Generic Name: acetaminophen / dextromethorphan / guaifenesin / phenylephrine

Brand name: Decorel Forte Plus Cold/Cough, Mucinex Fast-Max, Mucinex Fast-Max Cold and Flu, Mucinex Fast-Max Congestion and Cold, Mucinex Fast-Max Severe Cold, Tylenol Cold Multi-Symptom Severe Daytime, Tylenol Cold Head Congestion Severe, Non-Pseudo Cold Relief, Phenflu DM, Sudafed PE Cold & Cough, Cold & Cough PE, Cold Head Congestion Severe Daytime, Cold Multi-Symptom Severe Daytime Cool Ice, Tylenol Cold & Flu Severe, Mucinex Children's Multi-Symptom Cold & Fever, Mucinex Fast-Max Cold, Flu & Sore Throat, Mucinex Fast-Max Severe Congestion & Cold, Cough & Sore Throat, DayQuil Severe Cold & Flu, Adult Cold, Cold & Flu Severe, Mucinex Sinus-Max Severe Congestion Relief, Delsym Cough + Cold Daytime, Severe Day Time Cold & Flu, Mucinex Fast-Max Cold & Flu, Mucinex Sinus-Max Pressure, Pain & Cough

Synonyms: n.a.

What is Sudafed PE Pressure+Pain+Cold?