Drug search by name

Duzallo and Trimox

Determining the interaction of Duzallo and Trimox and the possibility of their joint administration.

Check result:

Duzallo <> Trimox

Relevance: 16.05.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Coadministration of allopurinol with ampicillin or amoxicillin may increase the risk of skin rash. The mechanism of interaction is unknown, and it is unclear whether the condition of hyperuricemia or the actual exposure to allopurinol is responsible. In a retrospective study, 15 out of 67 patients (22%) who took ampicillin with allopurinol developed a skin rash, compared to 94 out of 1257 patients (7.5%) who took ampicillin without allopurinol. An updated study by the same group of investigators consisted of 252 patients who took ampicillin with allopurinol and 4434 who took ampicillin alone. The incidence of rash was 13.9% in the allopurinol group and 5.7% in the ampicillin-only group. Similar results were reported for amoxicillin. Specifically, 8 out of 36 patients (22%) treated concomitantly with allopurinol developed a rash, compared to 52 out of 887 patients (5.9%) on amoxicillin without allopurinol. There is probably no need to avoid concomitant use of these drugs in patients who otherwise can take these drugs individually.

References

"Product Information. Zyloprim capsules (allopurinol)." Glaxo Wellcome, Research Triangle Park, NC.
Singer JZ, Wallace SL "The allopurinol hypersensitivity syndrome." Arthritis Rheum 29 (1986): 82-7
Boston Collaborative Drug Surveillance Program "Excess of ampicillin rashes associated with allopurinol or hyperuricemia." N Engl J Med 286 (1972): 505-7
Jick H, Porter JB "Potentiation of ampicillin skin reactions by allopurinol or hyperuricemia." J Clin Pharmacol 21 (1981): 456-8

Duzallo

Generic Name: allopurinol / lesinurad

Brand name: Duzallo

Synonyms: n.a.

What is Duzallo?

Trimox

Generic Name: amoxicillin

Brand name: Moxatag, Trimox, Amoxil

Synonyms: n.a.

What is Trimox?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions