Drug search by name

Dynacirc and PCE Dispertab

Determining the interaction of Dynacirc and PCE Dispertab and the possibility of their joint administration.

Check result:

Dynacirc <> PCE Dispertab

Relevance: 24.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Erythromycin can increase the blood levels and effects of isradipine. This may increase the risk of serious side effects such as irregular heart rhythm, fluid retention, swelling, heart failure, and excessively low blood pressure. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. You should seek immediate medical attention if you experience sudden, unexplained weight gain; swelling of the hands, ankles, or feet; chest pain; or difficulty breathing during treatment with these medications. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration of isradipine and erythromycin or clarithromycin may increase isradipine serum concentrations. The presumed mechanism is inhibition of CYP450 3A4 metabolism by the macrolide antibiotics.

MANAGEMENT: When macrolide antibiotics are coadministered with isradipine, patients should be monitored for adverse effects such as flushing, ankle edema, or palpitations.

References

Agencia Española de Medicamentos y Productos Sanitarios Healthcare "Centro de información online de medicamentos de la AEMPS - CIMA. Available from: URL: https://cima.aemps.es/cima/publico/home.html." ([2018]):
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Dynacirc

Generic Name: isradipine

Brand name: Dynacirc, Dynacirc CR

Synonyms: DynaCirc

What is Dynacirc?

PCE Dispertab

Generic Name: erythromycin

Brand name: EES. Granules, EES-400 Filmtab, EryPed 200, EryPed 400, Ery-Tab, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, PCE Dispertab, E. E. S, EryPed, Erythrocin, Erythromycin Filmtabs, Erythromycin Lactobionate - IV

Synonyms: PCE Dispertab (Oral), PCE, PCE (Oral)

What is PCE Dispertab?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions