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Echothiophate Iodide and Quelicin

Determining the interaction of Echothiophate Iodide and Quelicin and the possibility of their joint administration.

Check result:

Echothiophate Iodide <> Quelicin

Relevance: 03.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using succinylcholine together with echothiophate iodide ophthalmic. Echothiophate iodide ophthalmic may increase the effects of succinylcholine. Contact your doctor immediately if your condition worsens or if you have breathing difficulty. You may need a dose adjustment if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Echothiophate ophthalmic solution, a long-acting anticholinesterase inhibitor, prolongs the neuromuscular blocking effects of succinylcholine. The mechanism appears to be inhibition of cholinesterase-mediated succinylcholine metabolism. Prolonged apnea or death may occur. Plasma cholinesterase activity may be reduced in patients with genetic abnormalities of plasma cholinesterase (e.g., patients heterozygous or homozygous for atypical plasma cholinesterase gene), pregnancy, severe liver or kidney disease, malignant tumors, infections, burns, anemia, decompensated heart disease, peptic ulcer, or myxedema.

MANAGEMENT: This combination should be avoided and a neuromuscular blocker other than succinylcholine should be considered in patients receiving chronic echothiophate therapy. If succinylcholine must be used, patients should be closely monitored for prolonged neuromuscular blocking effects. Some authorities recommend that echothiophate ophthalmic drops should be discontinued several months prior to administration of succinylcholine and/or consideration should be given to using a reduced dose of succinylcholine.

References

Cohen PJ, Reynolds RC, Naidl J "A simple test for abnormal pseudocholinesterase." Anesthesiology 32 (1970): 281-2
Cavallaro RJ, Krumperman LW, Kugler F "Effect of echothiophate therapy on the metabolism of succinylcholine in man." Anesth Analg 47 (1968): 570-4
Eilderton TE, farmati O, Zsigmond EK "Reduction in plasma cholinesterase levels after prolonged administration of echothiophate iodide eyedrops." Can Anaesth Soc J 15 (1968): 291-6
Lipson ML, Holmes JH, Ellis PP "Oral administration of pralidoxime chloride in echothiophate iodide therapy." Arch Ophthalmol 82 (1969): 830-5
Cerner Multum, Inc. "Australian Product Information." O 0
Kinyon GE "Anticholinesterase eye drops--need for caution." N Engl J Med 280 (1969): 53
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Kothary SP, Tether JE, Flynn KB, Zsigmond EK "Plasmacholinesterase activity in relation to the safe use of succinylcholine in myasthenic patients on chronic anticholinesterase treatment." Clin Pharmacol Ther 21 (1977): 108
Mone JG, Mathie WE "Qualitative and quantitative defects of pseudocholinestease activity." Anaesthesia 22 (1967): 55-68

Echothiophate Iodide

Generic Name: echothiophate iodide ophthalmic

Brand name: Phospholine Iodide

Synonyms: Echothiophate iodide ophthalmic

What is Echothiophate Iodide?

Quelicin

Generic Name: succinylcholine

Brand name: Anectine, Quelicin

Synonyms: n.a.

What is Quelicin?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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