Echothiophate Iodide and Succinylcholine Chloride
Determining the interaction of Echothiophate Iodide and Succinylcholine Chloride and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Ask your doctor before using succinylcholine together with echothiophate iodide ophthalmic. Echothiophate iodide ophthalmic may increase the effects of succinylcholine. Contact your doctor immediately if your condition worsens or if you have breathing difficulty. You may need a dose adjustment if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Echothiophate ophthalmic solution, a long-acting anticholinesterase inhibitor, prolongs the neuromuscular blocking effects of succinylcholine. The mechanism appears to be inhibition of cholinesterase-mediated succinylcholine metabolism. Prolonged apnea or death may occur. Plasma cholinesterase activity may be reduced in patients with genetic abnormalities of plasma cholinesterase (e.g., patients heterozygous or homozygous for atypical plasma cholinesterase gene), pregnancy, severe liver or kidney disease, malignant tumors, infections, burns, anemia, decompensated heart disease, peptic ulcer, or myxedema.
MANAGEMENT: This combination should be avoided and a neuromuscular blocker other than succinylcholine should be considered in patients receiving chronic echothiophate therapy. If succinylcholine must be used, patients should be closely monitored for prolonged neuromuscular blocking effects. Some authorities recommend that echothiophate ophthalmic drops should be discontinued several months prior to administration of succinylcholine and/or consideration should be given to using a reduced dose of succinylcholine.
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Generic Name: echothiophate iodide ophthalmic
Brand name: Phospholine Iodide
Synonyms: Echothiophate iodide ophthalmic
Generic Name: succinylcholine
Brand name: Anectine, Quelicin
Synonyms: Succinylcholine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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