Eculizumab and Niaspan

• Generic Name: eculizumab
• Dosage Forms: n.a.
• Other Brand Names: Soliris

Eculizumab is a monoclonal antibody. Eculizumab binds to proteins in the blood that can destroy red blood cells in people with genetic conditions that affect the natural defenses of red blood cells.

Eculizumab is used to prevent the breakdown of red blood cells in adults with paroxysmal nocturnal hemoglobinuria (PNH).

Eculizumab is also used to treat a rare chronic blood disease called atypical hemolytic uremic syndrome (aHUS) in adults and children who weigh at least 11 pounds (5 kilograms).

Eculizumab is also used to treat myasthenia gravis in adults.

Eculizumab is also used to treat neuromyelitis optica spectrum disorder (NMOSD) in adults.

Eculizumab is available only under a special program. You must be registered in the program and understand the risks and benefits of eculizumab.

Eculizumab may also be used for purposes not listed in this medication guide.

• Generic Name: niacin
• Dosage Forms: tablet, film coated, extended release
• Other Brand Names: B-3-50, B3-500-Gr, Niacin SR, Niacor, Niaspan ER, Slo-Niacin

Niaspan ER extended release works by reducing LDL ("bad") cholesterol and triglycerides and increasing HDL ("good") cholesterol. Niaspan contains niacin, also called nicotinic acid, a B vitamin (vitamin B3). It occurs naturally in plants and animals and is present in many multiple vitamin supplements.

Niaspan ER is used to lower cholesterol and triglycerides (types of fat) in the blood. It is also used to lower the risk of heart attack in people with high cholesterol who have already had a heart attack. It is sometimes used to treat coronary artery disease (also called atherosclerosis).

Niaspan ER may also be used for purposes not listed in this medication guide.