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Edecrin and Phenytoin injection

Determining the interaction of Edecrin and Phenytoin injection and the possibility of their joint administration.

Check result:

Edecrin <> Phenytoin injection

Relevance: 12.01.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Some hydantoins may reduce the gastrointestinal absorption of some loop diuretics. Serum diuretic concentrations and diuretic effects after oral dosing may be decreased. Data are available for furosemide and phenytoin only. Increases in diuretic dosage may be necessary.

References

Ahmad S "Renal insensitivity to frusemide caused by chronic anticonvulsant therapy." Br Med J 3 (1974): 657-9
Fine A, Henderson IS, Morgan DR "Malabsorption of frusemide caused by phenytoin." Br Med J 2 (1977): 1601-2

Edecrin

Generic Name: ethacrynic acid

Brand name: Edecrin, Sodium Edecrin, Edecrin Sodium

Synonyms: n.a.

What is Edecrin?

Phenytoin injection

Generic Name: phenytoin

Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt

Synonyms: Phenytoin

What is Phenytoin injection?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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