Edecrin Sodium and Lithium Syrup and Oral Solution

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ask your doctor before using ethacrynic acid together with lithium. Using ethacrynic acid together with lithium may increase the effects of lithium. This may cause diarrhea, vomiting, drowsiness, tremor, thirst, increased urination, lack of coordination, or muscle weakness. You may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Loop diuretics may increase serum lithium levels and potentiate the risk of lithium toxicity. The exact mechanism is unknown but may be related to the sodium loss induced by loop diuresis, which produces a compensatory increase in proximal tubular reabsorption of sodium along with lithium. Although a few studies using furosemide found no significant effect on serum lithium levels for up to 12 weeks of concomitant use, serious lithium toxicity has been reported, particularly in elderly patients. In a population-based case-control study of 10,615 patients older than 65 years who were receiving continuous lithium therapy for a total of 26,866 patient-years, 413 (4%) case patients were identified over a 10-year period who had at least one hospital admission for lithium toxicity. After adjustment for potential confounders, any exposure to a loop diuretic within the preceding 28 days of the episode was associated with a 1.7 relative risk of hospitalization for lithium toxicity compared to matched controls, and new exposure to a loop diuretic (defined as no other use of a loop diuretic in the preceding 365 days) was associated with a relative risk of 5.5. Overall, approximately 2.4% of all hospitalizations for lithium toxicity in this elderly cohort could be attributed to new use of a loop diuretic. There have also been individual case reports of patients developing lithium toxicity shortly after initiation of a loop diuretic. The risk for lithium toxicity may be further increased during concomitant sodium restriction.

MANAGEMENT: Loop diuretics should generally not be prescribed to patients receiving lithium unless close monitoring of serum lithium levels and electrolytes can be rendered. Lithium dose reductions may be required. Patients should be advised to notify their physician if they experience potential signs and symptoms of lithium toxicity such as drowsiness, dizziness, muscle weakness, vomiting, diarrhea, thirst, polyuria, tinnitus, tremor, ataxia, and blurred vision.

Edecrin Sodium

Generic Name: ethacrynic acid

Brand name: Sodium Edecrin, Edecrin, Edecrin Sodium

Synonyms: Sodium Edecrin

What is Edecrin Sodium?

Lithium Syrup and Oral Solution

Generic Name: lithium

Brand name: Lithobid, Eskalith, Lithonate, Lithotabs, Eskalith-CR

Synonyms: Lithium

What is Lithium Syrup and Oral Solution?