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Edecrin Sodium and Ofloxacin

Determining the interaction of Edecrin Sodium and Ofloxacin and the possibility of their joint administration.

Check result:

Edecrin Sodium <> Ofloxacin

Relevance: 12.05.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

The plasma concentration of lomefloxacin following administration of furosemide has been reported to be higher than after lomefloxacin alone. The area under the curve of lomefloxacin was increased and the total and renal clearances of lomefloxacin were decreased. A similar interaction may occur if other quinolones are administered with other loop diuretics. The loop diuretic may decrease the renal clearance of the quinolone by competing for tubular secretion. The clinical significance is unknown.

References

Sudoh T, Fujimura A, Shiga T, Sasaki M, Harada K, Tateishi T, Ohashi K, Ebihara A "Renal clearance of lomefloxacin is decreased by furosemide." Eur J Clin Pharmacol 46 (1994): 267-9

Edecrin Sodium

Generic Name: ethacrynic acid

Brand name: Sodium Edecrin, Edecrin, Edecrin Sodium

Synonyms: Sodium Edecrin

What is Edecrin Sodium?

Ofloxacin

Generic Name: ofloxacin

Brand name: Floxin, Floxin IV.

Synonyms: Ofloxacin (Systemic)

What is Ofloxacin?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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