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Edluar and Flumazenil Injection

Determining the interaction of Edluar and Flumazenil Injection and the possibility of their joint administration.

Check result:

Edluar <> Flumazenil Injection

Relevance: 04.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

A case report has suggested that flumazenil may reverse coma and respiratory depression in patients experiencing zolpidem toxicity. Also, a small study has confirmed that flumazenil antagonizes the central effects of zolpidem and has suggested that the interaction may be attributable to pharmacodynamic effects.

References

Patat A, Naef MM, Vangessel E, Forster A, Dubruc C, Rosenzweig P "Flumazenil antagonizes the central effects of zolpidem, an imidazopyridine hypnotic." Clin Pharmacol Ther 56 (1994): 430-6
Lheureux P, Debailleul G, De Witte O, Askenasi R "Zolpidem intoxication mimicking narcotic overdose: response to flumazenil." Hum Exp Toxicol 9 (1990): 105-7

Edluar

Generic Name: zolpidem

Brand name: Edluar, Ambien, Ambien CR, Intermezzo, ZolpiMist

Synonyms: n.a.

What is Edluar?

Flumazenil Injection

Generic Name: flumazenil

Brand name: Romazicon

Synonyms: Flumazenil

What is Flumazenil Injection?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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